Indications And Dose
HIV-1 infection in combination with other antiretroviral drugs (initiated by a specialist) ▶BY MOUTH ▶Adult: 100 mg once daily
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Drug reference
HIV-1 infection in combination with other antiretroviral drugs (initiated by a specialist) ▶BY MOUTH ▶Adult: 100 mg once daily
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DUE TO INTERACTIONS ▶Manufacturer advises if concurrent use of moderate inducers of CYP3A4, dabrafenib, modafinil, or telotristat ethyl is unavoidable, increase dose to 100 mg twice daily. Manufacturer advises 100 mg twice daily with rifabutin.
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→Appendix 1: doravirine
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▶Common or very common Asthenia. diarrhoea. dizziness. drowsiness. gastrointestinal discomfort. gastrointestinal disorders. headache. hepatocellular injury. nausea. skin reactions. sleep disorders. vomiting ▶Uncommon Anxiety. arthralgia. concentration impaired. confusion. constipation. depression. electrolyte imbalance. hypertension. malaise. memory loss. mood altered. muscle tone increased. myalgia. paraesthesia. suicidal ideation ▶Rare or very rare Acute kidney injury. adjustment disorder . aggression. chest pain. chills. dyspnoea. hallucination. pain. rash pustular. renal disorder. thirst. tonsillar hypertrophy. urolithiases
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Manufacturer advises avoid—no information available.
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Manufacturer advises caution in severe impairment (no information available).
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 25, 3 ▶Pifeltro (Merck Sharp & Dohme Ltd) A Doravirine 100 mg Pifeltro 100mg tablets | 30 tablet P £471.41 Combinations available: Lamivudine with tenofovir disoproxil and doravirine, p. 690 Infection
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Missed doses If a dose is more than 12 hours late, the missed dose should not be taken and the next dose should be taken at the normal time. Driving and skilled tasks Manufacturer advises patients and carers should be counselled on the effects on driving and performance of skilled tasks—increased risk of fatigue, dizziness, and somnolence.
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100 mg once daily
First-line fragment. Read the complete Indications and Dose section above.
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