Names and pronunciation
(dor′a-vir′een/lam-i-voo′deen/ ten-oh-foh′veer) Delstrigo
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Drug reference
(dor′a-vir′een/lam-i-voo′deen/ ten-oh-foh′veer) Delstrigo
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Func. class.: Antiretroviral
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Chem. class.: Nonnucleoside reverse transcriptase inhibitor (NNRTI), nucleo- side reverse transcriptase inhibitor (NRTI)
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USES: Human immunodeficiency virus (HIV) infection in antiretroviral-naive adults
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CONTRAINDICATIONS: Hyper sensitivity Precautions: Alcoholism, autoimmune dis- orders, bipolar disease, breastfeeding, chil- dren, depression, driving or operating haz- ardous machinery, geriatric patients, Graves’ disease, Guillain-Barré syndrome, hepatic disease, hepatitis B and HIV coinfection, hepatitis C and HIV coinfection, HIV resis- tance, immune reconstitution syndrome, pregnancy, psychosis, substance abuse
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Black Box Warning: Hepatitis B exacer- bation
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DOSAGE AND ROUTES • Adult: PO 1 tablet (doravirine 100 mg; lamivudine 300 mg; tenofovir diso- proxil fumarate 300 mg) daily Concurrent treatment with rifabutin • Adult: PO 1 tablet (doravirine 100 mg; lamivudine 300 mg; tenofovir disoproxil fu- marate 300 mg) daily, then 12 hr later, give an additional 100 mg of doravirine by mouth each day of rifabutin concurrent therapy
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• Adult: PO 1 tablet (doravirine 100 mg; lamivudine 300 mg; tenofovir diso- proxil fumarate 300 mg) daily Concurrent treatment with rifabutin
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• Adult: PO 1 tablet (doravirine 100 mg; lamivudine 300 mg; tenofovir disoproxil fu- marate 300 mg) daily, then 12 hr later, give an additional 100 mg of doravirine by mouth each day of rifabutin concurrent therapy
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