Names and pronunciation
(docks-ill′ah-meen/peer-reh- dock′seen) Diclegis, Bonjesta, Diclectin/B6
PDF page 434
Loading InternPractice…
Drug reference
(docks-ill′ah-meen/peer-reh- dock′seen) Diclegis, Bonjesta, Diclectin/B6
PDF page 434
Func. class.: Antiemetic
PDF page 434
ACTION: Unknown, may act by anticholinergic effect
PDF page 435
USES: Nausea and vomiting of preg- nancy in women who do not respond to other treatment
PDF page 435
CONTRAINDICATIONS: Hyper sensitivity
PDF page 435
SIDE EFFECTS CNS: Somnolence, dizziness, drowsiness
PDF page 435
INTERACTIONS Increase: CNS depression—CNS depres- sants, MAOIs, alcohol, avoid using together Drug/Food • Decrease: effect by food NURSING CONSIDERATIONS
PDF page 435
DOSAGE AND ROUTES • Adult pregnant females: PO 2 tablets (on an empty stomach) at bedtime, on day 1; if dose controls symptoms the next day, con- tinue regimen. If symptoms persist on the afternoon of day 2, continue 2 tablets at bedtime, then take 3 tablets starting on day 3 (1 tablet in AM and 2 tablets at bedtime); if symptoms are controlled, continue regimen. If symptoms persist, on day 4, take 4 tablets (1 tablet in AM, 1 tablet midafternoon, and 2 tablets at bedtime); max 4 tablets/day. Use only as needed
PDF page 435
Available forms: Tablets extended release: doxylamine 20 mg/pyridoxine 20 mg; tablets delayed release: doxylamine 10 mg/pyridoxine 10 mg Administer • Give whole on empty stomach with 8 oz of water • Take as prescribed, do not double or miss doses • Store at room temperature, protect from light
PDF page 435
Assess: • Anticholinergic effects: monitor for dry mouth, constipation, dizziness • CNS changes: Assess for dizziness, drowsiness, and somnolence; caution D against driving or other hazardous activi- ties until response is known • Pregnancy/breastfeeding: Used in pregnancy to decrease nausea/vomiting; do not breastfeed
PDF page 435
Evaluate: • Therapeutic response • Decreasing nausea/vomiting of pregnancy
PDF page 435
Patient and caregiver information: • To report anticholinergic effects • Not to drive or perform other hazard- ous activities until response is known • Pregnancy/breastfeeding: Do not breastfeed HIGH ALERT
PDF page 435
PHARMACOKINETICS Doxylamine: Onset unknown, peak 1.7-8 hr, duration unknown; pyridox- ine: Onset unknown, peak ½-4.7 hr; half-life: doxylamine: 12½ hr, pyridoxine: ½ hr
PDF page 435
• Adult pregnant females: PO 2 tablets (on an empty stomach) at bedtime, on day 1; if dose controls symptoms the next day, con- tinue regimen. If symptoms persist on the afternoon of day 2, continue 2 tablets at bedtime, then take 3 tablets starting on day 3 (1 tablet in AM and 2 tablets at bedtime); if symptoms are controlled, continue regimen. If symptoms persist, on day 4, take 4 tablets (1 tablet in AM, 1 tablet midafternoon, and 2 tablets at bedtime); max 4 tablets/day. Use only as needed
PDF page 435