Drug Action
Doxylamine is a first-generation antihistamine which selectively binds H1 receptors in the brain; pyridoxine (vitamin B6) is a water-soluble vitamin.
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Drug reference
Doxylamine is a first-generation antihistamine which selectively binds H1 receptors in the brain; pyridoxine (vitamin B6) is a water-soluble vitamin.
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Nausea and vomiting in pregnancy ▶BY MOUTH ▶Adult: 20/20 mg once daily for 2 days, to be taken at bedtime; increased if necessary to 10/10 mg, to be taken in the morning and 20/20 mg, to be taken at bedtime; increased if necessary to 10/10 mg, to be taken in the morning, 10/10 mg, to be taken mid- afternoon and 20/20 mg, to be taken at bedtime; maximum 40/40 mg per day DOSE EQUIVALENCE AND CONVERSION ▶Dose expressed as x/y mg of doxylamine/pyridoxine.
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Asthma. bladder neck obstruction. increased intra-ocular pressure. narrow angle glaucoma. pyloroduodenal obstruction. stenosing peptic ulcer
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Scottish Medicines Consortium (SMC) decisions SMC No. SMC2140 The Scottish Medicines Consortium has advised (May 2019) that doxylamine succinate and pyridoxine hydrochloride (Xonvea ®) is not recommended for use within NHS Scotland for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management, as the clinical and economic case was not demonstrated. All Wales Medicines Strategy Group (AWMSG) decisions AWMSG No. 2170 The All Wales Medicines Strategy Group has advised (June 2019) that doxylamine succinate with pyridoxine hydrochloride (Xonvea ®) is not recommended for use within NHS Wales for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management, as the case for cost- effectiveness has not been proven.
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→Appendix 1: antihistamines, sedating
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▶Common or very common Dizziness. drowsiness. dry mouth. fatigue ▶Frequency not known Akathisia. anxiety. chest discomfort . constipation. diarrhoea. disorientation. dyspnoea. gastrointestinal discomfort. headaches. hyperhidrosis. irritability. malaise. palpitations. paraesthesia. skin reactions. sleep disorders. tachycardia. urinary disorders. vertigo. vision disorders
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There can be variation in the licensing of different medicines containing the same drug. Gastro-resistant tablet CAUTIONARY AND ADVISORY LABELS 2, 23, 25 ▶Xonvea (Alliance Pharmaceuticals Ltd) Doxylamine succinate 10 mg, Pyridoxine hydrochloride 10 mg Xonvea 10mg/10mg gastro-resistant tablets | 20 tablet P £28.50 DT = £28.50 ANTIEMETICS AND ANTINAUSEANTS › CANNABINOIDS
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Driving and skilled tasks Manufacturer advises patients and carers should be counselled on the effects on driving and performance of skilled tasks—increased risk of somnolence and dizziness.
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20/20 mg once daily for 2 days, to be taken at
First-line fragment. Read the complete Indications and Dose section above.
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