Drug Action
Droperidol is a butyrophenone, structurally related to haloperidol, which blocks dopamine receptors in the chemoreceptor trigger zone. Nervous system
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Drug reference
Droperidol is a butyrophenone, structurally related to haloperidol, which blocks dopamine receptors in the chemoreceptor trigger zone. Nervous system
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Prevention and treatment of postoperative nausea and vomiting ▶BY INTRAVENOUS INJECTION ▶Adult: 0.625–1.25 mg, dose to be given 30 minutes before end of surgery, then 0.625–1.25 mg every 6 hours as required ▶Elderly: 625 micrograms, dose to be given 30 minutes before end of surgery, then 625 micrograms every 6 hours as required Prevention of nausea and vomiting caused by opioid analgesics in postoperative patient-controlled analgesia (PCA) ▶BY INTRAVENOUS INJECTION ▶Adult: 15–50 micrograms of droperidol for every 1 mg of morphine in PCA, reduce dose in elderly; maximum 5 mg per day
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Bradycardia. comatose states. hypokalaemia. hypomagnesaemia. phaeochromocytoma. QT-interval prolongation
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Chronic obstructive pulmonary disease. CNS depression. electrolyte disturbances. history of alcohol abuse. respiratory failure
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→Appendix 1: droperidol
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▶Uncommon Anxiety. oculogyration ▶Rare or very rare Blood disorder. cardiac arrest. confusion . dysphoria ▶Frequency not known Coma. epilepsy. hallucination. oligomenorrhoea. respiratory disorders. SIADH. syncope
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Limited information available—avoid repeated administration.
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Manufacturer advises caution. Dose adjustments ▶When used for Prevention and treatment of postoperative nausea and vomiting Manufacturer advises maximum 625 micrograms repeated every 6 hours as required. ▶When used for Prevention of nausea and vomiting caused by opioid analgesics in postoperative patient-controlled analgesia Manufacturer advises dose reduction (no information available).
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Dose adjustments In postoperative nausea and vomiting, max. 625 micrograms repeated every 6 hours as required. For nausea and vomiting caused by opioid analgesics in postoperative patient-controlled analgesia, reduce dose.
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Continuous pulse oximetry required if risk of ventricular arrhythmia—continue for 30 minutes following administration.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Droperidol (Non-proprietary) Droperidol 2.5 mg per 1 ml Droperidol 2.5mg/1ml solution for injection ampoules | 10 ampoule P s ▶Xomolix (Kyowa Kirin Ltd) Droperidol 2.5 mg per 1 ml Xomolix 2.5mg/1ml solution for injection ampoules | 10 ampoule P £39.40 eiiii F 401
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625 micrograms, dose to be given 30 minutes
First-line fragment. Read the complete Indications and Dose section above.
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