Names and pronunciation
(doo-pil′-ue-mab) Dupixent
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Drug reference
(doo-pil′-ue-mab) Dupixent
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Func. class.: Dermatologicals
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USES: Moderate to severe atopic dermatitis in patients whose disease is not adequately controlled with topical therapies or when those therapies are not advised, add-on maintenance in moderate-severe asthma with eosino- phils, phenotype, or oral corticoste- roid–dependent asthma; add-on main- tenance treatment of poorly controlled chronic rhinosinusitis with nasal polyps
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DOSAGE AND ROUTES Atopic dermatitis • Adult/child 6-17 yr ≥60 kg: SUBCUT Initially, 600 mg (administered as two 300-mg injections); maintenance dosing: 300 mg every other week • Child 6-17 yr 30-<60 kg yr SUB- CUT Initially, 400 mg (two 200-mg injections), then 200 mg every other week Asthma • Adult/ child ≥12 yr: SUBCUT Loading, 400 mg (two 200-mg injections) fol- lowed by 200 mg every other week or an initial loading dose of 600 mg (two 300-mg injections) followed by 300 mg every other week
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Available forms: Injection: 300-mg/2- mL single-dose syringes HIGH ALERT
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• Adult/child 6-17 yr ≥60 kg: SUBCUT Initially, 600 mg (administered as two 300-mg injections); maintenance dosing: 300 mg every other week
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• Adult/ child ≥12 yr: SUBCUT Loading, 400 mg (two 200-mg injections) fol- lowed by 200 mg every other week or an initial loading dose of 600 mg (two 300-mg injections) followed by 300 mg every other week
PDF pages 441, 442