Names and pronunciation
eck-u-liz’uh-mob Solaris
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Drug reference
eck-u-liz’uh-mob Solaris
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Func. class.: Monoclonal antibody
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USES: Hemolysis in paroxysmal noc- turnal hemoglobinuria (PNH), atypi- cal hemolytic-uremic syndrome (aHUS) to prevent complement-mediated throm- botic microangiopathy
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CONTRAINDICATIONS: Hyper- sensitivity
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Black Box Warning: Life-threatening and fatal meningococcal infections
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DOSAGE AND ROUTES Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH): • Adult: IV INF 600 mg q7days × 4 wk, then 900 mg, and then 900 mg q14days Atypical hemolytic-uremic syn- drome (aHUS) to prevent comple- ment-mediated thrombotic microan- giopathy • Adult: IV INF 900 mg q7days × 4 wk, then 1200 mg, and then 1200 mg q14days • Child/adolescent ≥40 kg: 900 mg q7days × 4 wk, then 1200 mg, and then 1200 mg q14days • Child/adolescent 30-39 kg: 600 mg q7days × 4 wk, then 900 mg on wk 5 and then 900 mg q14days • Child/adolescent 20-29 kg: 600 mg q7days × 3 wk, then 600 mg q14days • Child/adolescents 10-19 kg: IV INF 600 mg single dose, then after 7 days 300 mg, then 300 mg q14days • Infant/child >2 mo and 5-9 kg IV INF: 300 mg q7days × 2 wk, then 300 mg q21days Anti-acetylcholine antibody-positive generalized myasthenia gravis • Adults: IV INF 900 mg q7days × 4 wk, then 1200 mg, and then 1200 mg q14days, usually for 12 wk Anti-aquaporin-4 (AQP4) antibody- positive neuromyelitis optica spec- trum disorder (NMOSD) • Adult: IV INF 900 mg q7days for the first 4 wk, then 1200 mg, and then 1200 mg q14days
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Available forms: Injection 100 mg/mL (300-mg single-use vial)
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• Child/adolescent ≥40 kg: 900 mg q7days × 4 wk, then 1200 mg, and then 1200 mg q14days
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• Child/adolescent 30-39 kg: 600 mg q7days × 4 wk, then 900 mg on wk 5 and then 900 mg q14days
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• Child/adolescent 20-29 kg: 600 mg q7days × 3 wk, then 600 mg q14days
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• Child/adolescents 10-19 kg: IV INF 600 mg single dose, then after 7 days 300 mg, then 300 mg q14days
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• Infant/child >2 mo and 5-9 kg IV INF: 300 mg q7days × 2 wk, then 300 mg q21days Anti-acetylcholine antibody-positive generalized myasthenia gravis
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