Names and pronunciation
(ee′de-tate) Calcium Disodium Versenate
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Drug reference
(ee′de-tate) Calcium Disodium Versenate
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Func. class.: Heavy metal antagonist (antidote, chelating agent)
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USES: Lead poisoning, acute lead encephalopathy
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CONTRAINDICATIONS: Hypersensitivity, anuria, poisoning of other metals, severe renal disease, hepatitis
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Black Box Warning: Child <3 yr, in- creased ICP, encephalopathy
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DOSAGE AND ROUTES Lead mobilization test (lead toxicity 25-45 mcg/dL) • Adult/adolescent: IV INFUSION 500 mg/m2 over 1 hr or IM • Child: IV INFUSION 500 mg/m2 over E 1 hr or IM as single dose or 2 divided doses Acute lead encephalopathy (blood levels >70 mcg/dL) • Adult/adolescent/child/infant: IM/ IV 1500 mg/m2 as IV INFUSION over 12-24 hr in combination with dimer- caprol IM, give first dose ≥4 hr after initial dimercaprol, when urine flow established
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Available forms: Injection 200 mg/mL
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• Child: IV INFUSION 500 mg/m2 over E 1 hr or IM as single dose or 2 divided doses Acute lead encephalopathy (blood levels >70 mcg/dL)
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• Adult/adolescent/child/infant: IM/ IV 1500 mg/m2 as IV INFUSION over 12-24 hr in combination with dimer- caprol IM, give first dose ≥4 hr after initial dimercaprol, when urine flow established
PDF page 447