Drug reference

Efavirenz with emtricitabine and tenofovir disoproxil

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 707

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

HIV infection stabilised on antiretroviral therapy for more than 3 months ▶BY MOUTH ▶Adult: 1 tablet once daily

PDF page 707

Safety

Interactions

→Appendix 1: efavirenz. tenofovir disoproxil

PDF page 707

Hepatic Impairment

Manufacturer advises caution in mild impairment; avoid in moderate to severe impairment (increased risk of hepatic side-effects).

PDF page 707

Renal Impairment

Avoid Atripla ® if eGFR less than 50 mL/minute/1.73 m2.

PDF page 707

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 23, 25 ▶Efavirenz with emtricitabine and tenofovir disoproxil (Non- proprietary) Emtricitabine 200 mg,Tenofovir disoproxil (as Tenofovir disoproxil fumarate) 245 mg, Efavirenz 600 mg Efavirenz 600mg / Emtricitabine 200mg / Tenofovir disoproxil 245mg tablets | 30 tablet P £479.58–£532.87 ▶Atripla (Gilead Sciences International Ltd) Emtricitabine 200 mg,Tenofovir disoproxil (as Tenofovir disoproxil fumarate) 245 mg, Efavirenz 600 mg Atripla 600mg/200mg/245mg tablets | 30 tablet P £532.87

PDF page 707

Clinical care

Patient And Carer Advice

Missed doses If a dose is more than 12 hours late, the missed dose should not be taken and the next dose should be taken at the normal time.

PDF page 707

Dose text by age group

Adult

1 tablet once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 707

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Efavirenz with emtricitabine and tenofovir disoproxil

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 707

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

HIV infection stabilised on antiretroviral therapy for more than 3 months ▶BY MOUTH ▶Adult: 1 tablet once daily

PDF page 707

Safety

Interactions

→Appendix 1: efavirenz. tenofovir disoproxil

PDF page 707

Hepatic Impairment

Manufacturer advises caution in mild impairment; avoid in moderate to severe impairment (increased risk of hepatic side-effects).

PDF page 707

Renal Impairment

Avoid Atripla ® if eGFR less than 50 mL/minute/1.73 m2.

PDF page 707

Dose and formulations

Medicinal Forms

PDF page 707

Clinical care

Patient And Carer Advice

Missed doses If a dose is more than 12 hours late, the missed dose should not be taken and the next dose should be taken at the normal time.

PDF page 707

Dose text by age group

Adult

1 tablet once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 707

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.