Therapeutic Action
Trypanocide
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Drug reference
Trypanocide
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Meningoencephalitic stage of African trypanosomiasis due to T.b. gambiense, in combination with nifurtimox (first choice treatment) or in monotherapy if nifurtimox is not available or is contra- indicated
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May cause: haematological disorders (anaemia, leucopenia, thrombocytopenia), gastrointestinal disturbances (diarrhoea, abdominal pain, vomiting), seizures, tremor, fever, deep tissue infection, headache, alopecia, dizziness. The catheter must be handled with great attention to avoid local or general bacterial superinfections: thoroughly disinfect the insertion site, protect the site with a sterile dressing, ensure secure catheter fixation and change the catheter every 48 hours or earlier in the event of phlebitis. Pregnancy: CONTRA-INDICATED unless, due to the mother’s general condition, treatment cannot be delayed until after delivery.
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10 g in 50 ml ampoule (200 mg/ml) to be diluted in 250 ml bag of water for injection (or, if not available, 0.9% sodium chloride), for IV infusion administered over 2 hours
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In combination with nifurtimox Child and adult: 200 mg/kg every 12 hours for 7 days In monotherapy Child under 12 years: 150 mg/kg every 6 hours for 14 days Child 12 years and over and adult: 100 mg/kg every 6 hours for 14 days
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When administering nifurtimox-eflornithine combined therapy, the dosage of nifurtimox in children and adults is 5 mg/kg every 8 hours for 10 days. Eflornithine is also called difluoromethylornithine or DFMO.
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– Below 25 °C Diluted solution must be kept refrigerated (2 °C to 8 °C) and used within 24 hours.
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200 mg/kg every 12 hours for 7 days
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150 mg/kg every 6 hours for 14 days
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100 mg/kg every 6 hours for 14 days
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