Names and pronunciation
(el-ex-a-kaf′tor/tez-a-kaf′tor/eye- va-kaf′tor) Trikafta Func. Class.: Metabolic
PDF page 453
Loading InternPractice…
Drug reference
(el-ex-a-kaf′tor/tez-a-kaf′tor/eye- va-kaf′tor) Trikafta Func. Class.: Metabolic
PDF page 453
USES: Cystic fibrosis (CF) with at least 1 F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene
PDF page 453
CONTRAINDICATIONS: Hyper- sensitivity
PDF page 453
DOSAGE AND ROUTES Cystic fibrosis (CF) with least 1 F508del mutation in the cystic fibrosis transmembrane conduc- tance regulator (CFTR) gene: • Adult/adolescent ≥12 yr: PO 2 tablets (elexacaftor 100 mg/tezacaftor 50 mg/ ivacaftor 75 mg) in the morning and 1 tablet ivacaftor 150 mg) in the evening 12 hr apart and given with fat-containing food Hepatic dose: • Adult/adolescent ≥12 yr: PO moder- ate impairment (Child-Pugh class B): 2 tablets containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg E PO once daily; NO ivacaftor 150-mg dose. Use with caution; this drug has not been studied in patients with mod- erate impairment; severe impairment (Child-Pugh class C): Do not use
PDF page 453
Available forms: Tablets 100-50-75 mg with ivacaftor 150 mg HIGH ALERT
PDF page 453
• Adult/adolescent ≥12 yr: PO 2 tablets (elexacaftor 100 mg/tezacaftor 50 mg/ ivacaftor 75 mg) in the morning and 1 tablet ivacaftor 150 mg) in the evening 12 hr apart and given with fat-containing food Hepatic dose:
PDF page 453
• Adult/adolescent ≥12 yr: PO moder- ate impairment (Child-Pugh class B): 2 tablets containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg E PO once daily; NO ivacaftor 150-mg dose. Use with caution; this drug has not been studied in patients with mod- erate impairment; severe impairment (Child-Pugh class C): Do not use
PDF page 453