Drug Action
Elvitegravir is an inhibitor of HIV integrase, which is an enzyme required for viral replication.
PDF page 702
Loading InternPractice…
Drug reference
Elvitegravir is an inhibitor of HIV integrase, which is an enzyme required for viral replication.
PDF page 702
HIV infection without resistance to other inhibitors of HIV integrase, in combination with low-dose ritonavir and atazanavir or lopinavir ▶BY MOUTH ▶Adult: 85 mg once daily, take at the same time as a once daily ritonavir-boosted regimen or with the first dose of a twice daily ritonavir-boosted regimen HIV infection without resistance to other inhibitors of HIV integrase, in combination with low-dose ritonavir and darunavir or fosamprenavir ▶BY MOUTH ▶Adult: 150 mg once daily, take with the first dose of a twice daily ritonavir-boosted regimen
PDF page 702
Elderly—limited information available
PDF page 702
→Appendix 1: elvitegravir
PDF page 702
▶Common or very common Diarrhoea. fatigue. headache. nausea. rash. vomiting ▶Uncommon Depression. dizziness. drowsiness. flatulence . gastrointestinal discomfort. insomnia. paraesthesia. suicidal ideation (in patients with history of depression or psychiatric illness). taste altered ▶Frequency not known Hyperglycaemia. osteonecrosis. weight increased
PDF page 702
Manufacturer advises women of child-bearing potential should use effective contraception during treatment (if using a hormonal contraceptive, it must contain norgestimate as the progestogen and at least 30 micrograms ethinylestradiol).
PDF page 702
Manufacturer advises avoid unless essential—limited data available.
PDF page 702
No licensed medicines listed. Combinations available: Elvitegravir with cobicistat, emtricitabine and tenofovir alafenamide, p. 686. Elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil, p. 686
PDF page 702
Missed doses Manufacturer advises if a dose is more than 18 hours late, the missed dose should not be taken and the next dose should be taken at the normal time. If vomiting occurs within 1 hour of taking a dose, a replacement dose should be taken.
PDF page 702
85 mg once daily, take at the same time as a
First-line fragment. Read the complete Indications and Dose section above.
PDF page 702
150 mg once daily, take with the first dose of a
First-line fragment. Read the complete Indications and Dose section above.
PDF page 702