Names and pronunciation
(em-a-pal′ue-mab) Gamifant
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Drug reference
(em-a-pal′ue-mab) Gamifant
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Func. class.: Immunomodulator
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Chem. class.: Monoclonal antibody
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USES: Treatment of primary hemo- phagocytic lymphohistiocytosis (HLH) with refractory, recurrent, or progressive disease or intolerance with conventional HLH therapy
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CONTRAINDICATIONS Hypersensitivity
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DOSAGE AND ROUTES • Adults/children: IV 1 mg/kg/dose over 1 hr twice per week (every 3 to 4 days). A dose increase on day 3 (to 3 mg/ kg/dose), days 6 to 8 (to 6 mg/kg/dose), and day 9 onwards (to 10 mg/kg/dose) may be needed
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Available forms: Injection 10 mg/2mL, 50 mg/mL, 100 mg/mL single dose See Appendix B
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• Adults/children: IV 1 mg/kg/dose over 1 hr twice per week (every 3 to 4 days). A dose increase on day 3 (to 3 mg/ kg/dose), days 6 to 8 (to 6 mg/kg/dose), and day 9 onwards (to 10 mg/kg/dose) may be needed
PDF page 459