Drug reference
Type 2 diabetes mellitus not controlled by metformin alone or by metformin in combination with other Endocrine system antidiabetic drugs or insulin ▶BY MOUTH ▶Adult 18–84 years: 5/850–5/1000 mg twice daily, based on patient’s current metformin dose, increased if necessary to 12.5/850–12.5/1000 mg twice daily ▶Adult 85 years and over: Initiation not recommended
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DUE TO INTERACTIONS ▶Dose of concomitant insulin or drugs that stimulate insulin secretion may need to be reduced. DOSE EQUIVALENCE AND CONVERSION ▶The proportions are expressed in the form "x"/"y" where "x" and "y" are the strengths in milligrams of empagliflozin and metformin respectively.
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Scottish Medicines Consortium (SMC) decisions SMC No. 1092/15 The Scottish Medicines Consortium has advised (October 2015) that empagliflozin with metformin (Synjardy ®) is accepted for restricted use within NHS Scotland in patients for whom a fixed dose combination of empagliflozin and metformin is an appropriate choice of therapy, or when use of a sulfonylurea is considered inappropriate.
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→Appendix 1: empagliflozin. metformin
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 21 ▶Synjardy (Boehringer Ingelheim Ltd) A Empagliflozin 12.5 mg, Metformin hydrochloride 850 mg Synjardy 12.5mg/850mg tablets | 56 tablet P £36.59 DT = £36.59 Empagliflozin 5 mg, Metformin hydrochloride 850 mg Synjardy 5mg/850mg tablets | 56 tablet P £36.59 DT = £36.59 Empagliflozin 12.5 mg, Metformin hydrochloride 1 gram Synjardy 12.5mg/1000mg tablets | 56 tablet P £36.59 DT = £36.59 Empagliflozin 5 mg, Metformin hydrochloride 1 gram Synjardy 5mg/1000mg tablets | 56 tablet P £36.59 DT = £36.59
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5/850–5/1000 mg twice daily, based
First-line fragment. Read the complete Indications and Dose section above.
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Initiation not recommended
First-line fragment. Read the complete Indications and Dose section above.
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