Names and pronunciation
(e-nal′a-pril/e-nal′a-pril-at) Vasotec
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Drug reference
(e-nal′a-pril/e-nal′a-pril-at) Vasotec
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Func. class.: Antihypertensive
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Chem. class.: Angiotensin-converting enzyme (ACE) inhibitor
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USES: Hypertension, HF, left ventricu- lar dysfunction
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CONTRAINDICATIONS: Hyper- sensitivity, history of angioedema, ACE inhibitors
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Black Box Warning: Pregnancy second/ third trimester Precautions: Breastfeeding, renal dis- ease, hyperkalemia, hepatic failure, dehydration, bilateral renal artery/aor- tic stenosis
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DOSAGE AND ROUTES Hypertension • Adult: PO 2.5-5 mg/day, may in- crease or decrease to desired re- sponse, range 10-40 mg/day in 1-2 di- vided doses; IV 0.625-1.25 mg q6hr over 5 min • Child: PO 0.08 mg/kg/day in 1-2 di- vided doses, max 0.58 mg/kg/day • Child: IV 5-10 mcg/kg/dose q8-24hr Heart failure • Adult: PO 2.5-20 mg/day in 2 di- vided doses, max 40 mg/day in divided doses Left ventricular cardiac dysfunction, asymptomatic • Adult: PO 2.5 mg bid, titrate to max 10 mg bid, as tolerated; diuretic dose may require adjustment; monitor for ≥2 hr for hypotension Renal disease • Adult: PO 2.5 mg/day (CCr <30 mL/min), increase gradually; IV CCr >30 mL/min, 1.25 mg q6hr; CCr <30 mL/min, 0.625 mg as one-time dose, increase as per B/P • Child >1 mo: PO/IV CCr <30 mL/min contraindicated Hypertensive emergency/urgency (unlabeled) • Adult: IV 1.25-5 mg q6hr
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Available forms: Enalapril: tablets 2.5, 5, 10, 20 mg; oral solution 1 mg/ mL; enalaprilat: injection 1.25 mg/mL
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• Adult: PO 2.5-5 mg/day, may in- crease or decrease to desired re- sponse, range 10-40 mg/day in 1-2 di- vided doses; IV 0.625-1.25 mg q6hr over 5 min
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• Child: PO 0.08 mg/kg/day in 1-2 di- vided doses, max 0.58 mg/kg/day
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• Child: IV 5-10 mcg/kg/dose q8-24hr Heart failure
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• Adult: PO 2.5-20 mg/day in 2 di- vided doses, max 40 mg/day in divided doses Left ventricular cardiac dysfunction, asymptomatic
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• Adult: PO 2.5 mg bid, titrate to max 10 mg bid, as tolerated; diuretic dose may require adjustment; monitor for ≥2 hr for hypotension Renal disease
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• Adult: PO 2.5 mg/day (CCr <30 mL/min), increase gradually; IV CCr >30 mL/min, 1.25 mg q6hr; CCr <30 mL/min, 0.625 mg as one-time dose, increase as per B/P
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• Child >1 mo: PO/IV CCr <30 mL/min contraindicated Hypertensive emergency/urgency (unlabeled)
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• Adult: IV 1.25-5 mg q6hr
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