Therapeutic Action
Angiotensin converting enzyme inhibitor (ACE)
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Drug reference
Angiotensin converting enzyme inhibitor (ACE)
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Hypertension Chronic heart failure
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Do not administer to patients with history of enalapril-related angioedema. May cause: hypotension, dizziness, headache, gastrointestinal disturbances, dry cough, renal impairment, hyperkalaemia, hyponatraemia; allergic reactions, angioedema; hypoglycaemia, haematological disorders. Avoid or monitor combination with: potassium-sparing diuretics and/or potassium chloride (risk of hyperkalaemia); non steroidal anti-inflammatory drugs and/or diuretics (risk of renal impairment). Monitor combination with: other antihypertensive drugs (risk of hypotension); drugs that provoke hypotension (e.g. haloperidol, amitriptyline); oral antidiabetics and insulin (risk of hypoglycaemia). Pregnancy: CONTRA-INDICATED Breast-feeding: no contra-indication at recommended doses
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5 mg and 20 mg tablets
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Hypertension Adult: start with 5 mg once daily, then increase the dose gradually every 1 to 2 weeks, according to blood pressure, up to 10 to 20 mg once daily (max. 40 mg daily) In elderly patients, patients taking a diuretic or patients with renal impairment: start with 2.5 mg once daily then adapt dose according to renal function. Chronic heart failure Adult: Week 1: 2.5 mg once daily for 3 days then 5 mg once daily Week 2: 10 mg once daily for 3 days then 20 mg once daily The usual dose is 10 to 20 mg once daily or 5 to 10 mg 2 times daily depending on tolerance (max. 40 mg daily). Reduce dosage in patients with renal impairment.
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According to clinical response
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– Below 25 °C
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start with 2.5 mg once daily then adapt dose according to renal function.
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