Drug Action
Entacapone prevents the peripheral breakdown of levodopa, by inhibiting catechol- O- methyltransferase, allowing more levodopa to reach the brain.
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Drug reference
Entacapone prevents the peripheral breakdown of levodopa, by inhibiting catechol- O- methyltransferase, allowing more levodopa to reach the brain.
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Adjunct to co-beneldopa or co-careldopa in Parkinson’s disease with ‘end-of-dose’ motor fluctuations (under expert supervision) ▶BY MOUTH ▶Adult: 200 mg, dose to be given with each dose of levodopa with dopa-decarboxylase inhibitor; maximum 2 g per day
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History of neuroleptic malignant syndrome. history of non-traumatic rhabdomyolysis. phaeochromocytoma
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Concurrent levodopa dose may need to be reduced by about 10–30%. ischaemic heart disease
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→Appendix 1: entacapone
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▶Common or very common Abdominal pain. confusion. constipation. diarrhoea. dizziness. dry mouth. fall. fatigue. hallucination. hyperhidrosis. ischaemic heart disease. movement disorders. nausea. sleep disorders. urine discolouration. vomiting ▶Uncommon Myocardial infarction ▶Rare or very rare Agitation. appetite decreased. skin reactions. weight decreased ▶Frequency not known Colitis. drowsiness. hair colour changes. hepatic disorders. impulse-control disorder. nail discolouration. neuroleptic malignant syndrome. rhabdomyolysis
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Avoid—no information available.
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Avoid—present in milk in animal studies.
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Manufacturer advises avoid.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 14 ▶Entacapone (Non-proprietary) Entacapone 200 mg Entacapone 200mg tablets | 30 tablet P £16.38 DT = £3.60 | 100 tablet P £11.93–£54.58 ▶Comtess (Orion Pharma (UK) Ltd) Entacapone 200 mg Comtess 200mg tablets | 30 tablet P £17.24 DT = £3.60 | 100 tablet P £57.45 Combinations available: Levodopa with carbidopa and entacapone, p. 436
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Avoid abrupt withdrawal.
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Patient counselling is advised (may colour urine reddish-brown, concomitant iron containing products).
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200 mg, dose to be given with each dose of
First-line fragment. Read the complete Indications and Dose section above.
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