Drug reference

entrectinib

Mosby’s 2024 Nursing Drug Reference

Source: Mosby’s 2024 Nursing Drug Reference
PDF pages: 475

Overview

Names and pronunciation

(en-trex′tih-nib) Rozlytrek

PDF page 475

Functional class

Func. class.: Antineoplastic orphan drug

PDF page 475

Chemical class

Chem. class.: Tyrosine kinase ROS1 inhibitor, tropomyosin receptor kinase (TRK) inhibitor

PDF page 475

Uses

USES: ROS1-positive non–small-cell lung cancer and NTRK gene fusion– positive solid tumors

PDF page 475

Safety

Contraindications

CONTRAINDICATIONS Hypersensitivity, pregnancy, breast- feeding

PDF page 475

Dose and formulations

Dosage and routes

DOSAGE AND ROUTES • Adult: PO 600 mg daily until disease progression or unacceptable toxicity

PDF page 475

Available forms

Available forms: Capsule 100, 200 mg

PDF page 475

Dose text by age group

Adult

• Adult: PO 600 mg daily until disease progression or unacceptable toxicity

PDF page 475

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

entrectinib

Mosby’s 2024 Nursing Drug Reference

Source: Mosby’s 2024 Nursing Drug Reference
PDF pages: 475

Overview

Names and pronunciation

(en-trex′tih-nib) Rozlytrek

PDF page 475

Functional class

Func. class.: Antineoplastic orphan drug

PDF page 475

Chemical class

Chem. class.: Tyrosine kinase ROS1 inhibitor, tropomyosin receptor kinase (TRK) inhibitor

PDF page 475

Uses

USES: ROS1-positive non–small-cell lung cancer and NTRK gene fusion– positive solid tumors

PDF page 475

Safety

Contraindications

CONTRAINDICATIONS Hypersensitivity, pregnancy, breast- feeding

PDF page 475

Dose and formulations

Dosage and routes

DOSAGE AND ROUTES • Adult: PO 600 mg daily until disease progression or unacceptable toxicity

PDF page 475

Available forms

Available forms: Capsule 100, 200 mg

PDF page 475

Dose text by age group

Adult

• Adult: PO 600 mg daily until disease progression or unacceptable toxicity

PDF page 475

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.