Names and pronunciation
(en-zal-u′ta-mide) Xtandi
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Drug reference
(en-zal-u′ta-mide) Xtandi
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Func. class.: Antineoplastic hormone
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Chem. class.: Nonsteroidal antiandrogen
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USES: Metastatic, castration-resistant prostate cancer in those who have received DOCEtaxel
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CONTRAINDICATIONS: Preg- nancy, women, hypersensitivity
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DOSAGE AND ROUTES • Adult: PO 160 mg (4 × 40-mg caps) daily. If a patient experiences a grade 3 or higher toxicity or an intolerable adverse effect, withhold dosing for 1 wk or until symptoms improve to grade 2 or less, then resume at the same or a reduced dosage (120 or 80 mg), if warranted • The concomitant use of strong CYP2C8 give 80 mg once daily; CYP3A4 inducers 240 mg daily
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Available forms: Capsules 40 mg
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• Adult: PO 160 mg (4 × 40-mg caps) daily. If a patient experiences a grade 3 or higher toxicity or an intolerable adverse effect, withhold dosing for 1 wk or until symptoms improve to grade 2 or less, then resume at the same or a reduced dosage (120 or 80 mg), if warranted
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