Names and pronunciation
(e-ren′ue-mab) Aimovig
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Drug reference
(e-ren′ue-mab) Aimovig
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Func. class.: CNS analgesic; antimi- graine agent
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Chem. class.: IgG2 monoclonal antibody
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ACTION: A human immunoglobulin G2 (IgG2) monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor. CGRP is involved in migraine pathophysiology
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USES: For the preventive treatment of migraine in adults
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CONTRAINDICATIONS: Hyper- sensitivity Precautions: Breastfeeding, latex hypersensitivity, pregnancy
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SIDE EFFECTS MISC: Antibody formation, injection site reaction, erythema
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INTERACTIONS None known
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DOSAGE AND ROUTES • Adult: SUBCUT 70 mg monthly, may use 140 mg monthly if needed
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Available forms: SureClick 70 mg/mL autoinjector solution for injection; solu- tion for injection single-use 70 mg/mL prefilled syringe
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Administer: Injectable administration • Visually inspect for particulate matter and discoloration prior to use; do not use if solution is cloudy or discolored or con- tains flakes or particles; product should be a clear to opalescent, colorless to light yellow solution Subcutaneous route • Product is intended for patient self- administration • Prior to use allow to warm to room temperature for at least 30 min, protected from direct sunlight • Do not shake • Clean injection site on the abdomen, thigh, or upper arm with an alcohol wipe; allow skin to dry • Do not leave cap off the autoinjector or prefilled syringe for more than 5 min; product will dry out • Do not inject into areas where skin is tender, bruised, red, or hard • If using the same body area for the 2 separate injections needed for the 140-mg dose, ensure that the second injection is not at same location • Storage: After removing the product from the refrigerator, it can be stored at room temperature between 68°F and 77°F (20°C and 25°C) for up to 7 days. Do not return to the refrigerator after room temperature Single-dose, prefilled SureClick autoinjector • When ready to inject, press the purple start button; a click will be heard, and the window will turn yellow Single-dose prefilled syringe • Using slow, constant pressure, push the plunger rod all the way down with thumb until the prefilled syringe stops moving • When finished, release thumb, and gently lift syringe off skin
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Evaluate: • Therapeutic response: decrease in se- verity and number of migraines Teach patient/family • To read the FDA-approved patient la- beling (Patient Information and Instruc- tions for Use) • Proper SUBCUT administration tech- nique, including aseptic technique, and how to use the single-dose prefilled auto- injector or single-dose prefilled syringe • To read and follow the Instructions for Use with each use of Aimovig • That if the 140-mg once-monthly dos- age is prescribed, to administer it as 2 separate SUBCUT injections of 70 mg each • Latex sensitivity: that the needle shield within the white cap of the Aimovig prefilled autoinjector and the gray needle cap of the Aimovig prefilled syringe contain dry natural rubber (a derivative of latex), which may cause allergic reactions in individuals sensi- tive to latex
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CLINICAL CONSIDERATIONS Assess • Migraines: time of day, aggravating and ameliorating effects, auras or halos, sensitivity to light, noise, diet • Pregnancy/breastfeeding: data are lacking
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PHARMACOKINETICS SUBCUT route: Peak 6 days, bioavailabil- ity 82%, half-life 28 days
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• Adult: SUBCUT 70 mg monthly, may use 140 mg monthly if needed
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