Indications And Dose
Prostate cancer ▶BY MOUTH ▶Adult: Initially 560–840 mg daily in divided doses; maintenance 140–1400 mg daily in divided doses
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Drug reference
Prostate cancer ▶BY MOUTH ▶Adult: Initially 560–840 mg daily in divided doses; maintenance 140–1400 mg daily in divided doses
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Peptic ulceration. severe cardiovascular disease. thromboembolic disorders
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Cardiovascular disease. cerebrovascular disease . conditions which might be aggravated by fluid retention (such as epilepsy or migraine). congestive heart failure. diabetes. hypercalcaemia. hypertension
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RISKS OF INCORRECT DOSING OF ORAL ANTI-CANCER MEDICINES See Cytotoxic drugs p. 938.
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→Appendix 1: alkylating agents
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▶Common or very common Anaemia. congestive heart failure. diarrhoea. embolism. fluid retention. gynaecomastia. headache. hepatic function abnormal. lethargy. leucopenia. myocardial infarction. nausea. thrombocytopenia. vomiting ▶Frequency not known Allergic dermatitis. angioedema. confusion. depression. erectile dysfunction. hypertension . muscle weakness. myocardial ischaemia
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Men should use effective contraceptive methods during treatment. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Manufacturer advises caution— monitor hepatic function; avoid in severe impairment.
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Manufacturer advises caution.
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Each dose should be taken not less than 1 hour before or 2 hours after meals and should not be taken with products containing calcium, magnesium or aluminium, including dairy products and antacid medication.
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There can be variation in the licensing of different medicines containing the same drug. Capsule CAUTIONARY AND ADVISORY LABELS 5, 23 ▶Estracyt (Pfizer Ltd) Estramustine phosphate (as Estramustine sodium phosphate) 140 mg Estracyt 140mg capsules | 100 capsule P £171.28
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Patients should be given advice on how to administer estramustine capsules.
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Initially 560–840 mg daily in divided doses;
First-line fragment. Read the complete Indications and Dose section above.
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