Drug reference

Factor IX fraction, dried

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 142, 143

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Treatment and prophylaxis of haemorrhage in congenital factor IX deficiency (haemophilia B) ▶BY INTRAVENOUS INJECTION, OR BY CONTINUOUS INTRAVENOUS INFUSION ▶Adult: (consult haematologist)

PDF page 142

Contra Indications

Disseminated intravascular coagulation

PDF page 142

Cautions

Risk of thrombosis—principally with low purity products. vaccination against hepatitis A and hepatitis B may be required (consult product literature)

PDF page 142

Prescribing And Dispensing Information

Dried factor IX fraction is prepared from human plasma by a suitable fractionation technique; it may also contain clotting factors II, VII, and X.

PDF page 143

Safety

Side Effects

▶Common or very common Anxiety. back pain. dyspnoea. hypersensitivity. nausea. sensation abnormal. skin reactions. vasodilation ▶Rare or very rare Angioedema. cardiac discomfort. chills. disseminated intravascular coagulation. embolism and thrombosis. headache. hypotension. lethargy. myocardial infarction. tachycardia. vomiting. wheezing ▶Frequency not known Nephrotic syndrome

PDF page 143

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder and solvent for solution for injection ▶AlphaNine (Grifols UK Ltd) Factor IX high purity 1000 unit AlphaNine 1,000unit powder and solvent for solution for injection vials | 1 vial P £390.00 Factor IX high purity 1500 unit AlphaNine 1,500unit powder and solvent for solution for injection vials | 1 vial P s ▶Haemonine (Biotest (UK) Ltd) Factor IX high purity 500 unit Haemonine 500unit powder and solvent for solution for injection vials | 1 vial P £300.00 (Hospital only) Factor IX high purity 1000 unit Haemonine 1,000unit powder and solvent for solution for injection vials | 1 vial P £600.00 (Hospital only) ▶Replenine-VF (Bio Products Laboratory Ltd) Factor IX high purity 500 unit Replenine-VF 500unit powder and solvent for solution for injection vials | 1 vial P £180.00 Factor IX high purity 1000 unit Replenine-VF 1,000unit powder and solvent for solution for injection vials | 1 vial P £360.00 Powder and solvent for solution for infusion ▶BeneFIX (Pfizer Ltd) Nonacog alfa 250 unit BeneFIX 250unit powder and solvent for solution for infusion vials | 1 vial P £151.80 (Hospital only) Nonacog alfa 500 unit BeneFIX 500unit powder and solvent for solution for infusion vials | 1 vial P £303.60 (Hospital only) Nonacog alfa 1000 unit BeneFIX 1,000unit powder and solvent for solution for infusion vials | 1 vial P £607.20 (Hospital only) Nonacog alfa 2000 unit BeneFIX 2,000unit powder and solvent for solution for infusion vials | 1 vial P £1,214.40 (Hospital only) Nonacog alfa 3000 unit BeneFIX 3,000unit powder and solvent for solution for infusion vials | 1 vial P £1,821.60 (Hospital only)

PDF page 143

Dose text by age group

Adult

(consult haematologist)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 142

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

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Drug reference

Factor IX fraction, dried

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 142, 143

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Treatment and prophylaxis of haemorrhage in congenital factor IX deficiency (haemophilia B) ▶BY INTRAVENOUS INJECTION, OR BY CONTINUOUS INTRAVENOUS INFUSION ▶Adult: (consult haematologist)

PDF page 142

Contra Indications

Disseminated intravascular coagulation

PDF page 142

Cautions

Risk of thrombosis—principally with low purity products. vaccination against hepatitis A and hepatitis B may be required (consult product literature)

PDF page 142

Prescribing And Dispensing Information

Dried factor IX fraction is prepared from human plasma by a suitable fractionation technique; it may also contain clotting factors II, VII, and X.

PDF page 143

Safety

Side Effects

PDF page 143

Dose and formulations

Medicinal Forms

PDF page 143

Dose text by age group

Adult

(consult haematologist)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 142

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.