Names and pronunciation
Andexxa
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Drug reference
Andexxa
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Func. class.: Antidote
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USES: For rivaroxaban reversal and apixaban reversal in patients with life- threatening or uncontrolled bleeding
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CONTRAINDICATIONS: None
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DOSAGE AND ROUTES Dose based on specific factor Xa inhibitor, dose of factor Xa inhibitor, and time since the patient’s last dose of factor Xa inhibitor • Adult: IV For rivaroxaban ≤10 mg or apixaban ≤5 mg within 8 hr or unknown timing of last dose or for any dose of ri- varoxaban or apixaban at 8 hr or more since timing of last dose, 400 mg IV BOL at 30 mg/min then 4 mg/min CONT IV INFUSION for up to 120 min • Adult: IV For rivaroxaban >10 mg, apixaban >5 mg, or unknown dose of either drug within 8 hr of timing of last dose, 800 mg IV BOL at 30 mg/min fol- lowed by 8 mg/min CONT IV INFUSION for up to 120 min. Resume anticoagulant therapy as soon as medically appropriate after factor Xa treatment
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Available forms: Powder for injection 100, 200 mg
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• Adult: IV For rivaroxaban ≤10 mg or apixaban ≤5 mg within 8 hr or unknown timing of last dose or for any dose of ri- varoxaban or apixaban at 8 hr or more since timing of last dose, 400 mg IV BOL at 30 mg/min then 4 mg/min CONT IV INFUSION for up to 120 min
PDF page 543
• Adult: IV For rivaroxaban >10 mg, apixaban >5 mg, or unknown dose of either drug within 8 hr of timing of last dose, 800 mg IV BOL at 30 mg/min fol- lowed by 8 mg/min CONT IV INFUSION for up to 120 min. Resume anticoagulant therapy as soon as medically appropriate after factor Xa treatment
PDF page 543