Drug reference
Treatment of benign gastric and duodenal ulceration ▶BY MOUTH ▶Adult: 40 mg once daily for 4–8 weeks, dose to be taken at night Maintenance treatment of duodenal ulceration ▶BY MOUTH ▶Adult: 20 mg once daily, dose to be taken at night Reflux oesophagitis ▶BY MOUTH ▶Adult: 20–40 mg twice daily for 6–12 weeks; maintenance 20 mg twice daily
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Famotidine can be sold to the public for adults and children over 16 years (provided packs do not contain more than 2 weeks’ supply) for the short-term symptomatic relief of heartburn, dyspepsia, and hyperacidity, and for the prevention of these symptoms when associated with consumption of food or drink including when they cause sleep disturbance (max. single dose 10 mg, max. daily dose 20 mg).
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→Appendix 1: H2 receptor antagonists
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▶Uncommon Appetite decreased. dry mouth. taste altered. vomiting ▶Rare or very rare Anxiety. chest tightness. drowsiness. insomnia. interstitial pneumonia. libido decreased. muscle cramps. neutropenia. paraesthesia. psychiatric disorder. seizures. severe cutaneous adverse reactions (SCARs)
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Manufacturer advises avoid unless potential benefit outweighs risk.
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Present in milk—not known to be harmful but manufacturer advises avoid.
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Seizures reported very rarely. Dose adjustments Use normal dose every 36–48 hours or use half normal dose if eGFR less than 50 mL/minute/1.73 m2. Gastro-intestinal system
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Famotidine (Non-proprietary) Famotidine 20 mg Famotidine 20mg tablets | 28 tablet P £22.00 DT = £21.99 Famotidine 40 mg Famotidine 40mg tablets | 28 tablet P £39.00 DT = £38.99 eiiii F 78
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40 mg once daily for 4–8 weeks, dose to be taken
First-line fragment. Read the complete Indications and Dose section above.
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20 mg once daily, dose to be taken at night
First-line fragment. Read the complete Indications and Dose section above.
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20–40 mg twice daily for 6–12 weeks;
First-line fragment. Read the complete Indications and Dose section above.
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