Therapeutic Action
Antifungal
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Drug reference
Antifungal
PDF page 402
Severe fungal infections, when oral administration is not possible: Cryptococcal meningitis, in combination with amphotericin B or flucytosine Severe oesophageal candidiasis
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Administer with caution to patients with hepatic or renal impairment, cardiac disorders (bradycardia, heart rhythm disorders, etc.). Reduce the dose by half in patients with renal impairment. May cause: gastrointestinal disturbances, headache, skin reactions sometimes severe, anaphylactic reactions; severe hepatic disorders, haematological (leukopenia, thrombocytopenia) and cardiac disorders (QT-prolongation). Stop treatment in the event of anaphylactic reaction, hepatic disorders or severe skin reaction. Avoid or monitor combination with: drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, haloperidol, mefloquine, pentamidine, quinine); warfarin, carbamazepine, phenytoin, rifabutin, benzodiazepines, calcium-channel blockers, certain antiretrovirals (e.g. nevirapine, zidovudine): increased plasma concentrations of these drugs; rifampicin: decreased plasma concentrations of fluconazole. Pregnancy and breast-feeding: use only in severe or life-threatening infections, particularly during the first trimester of pregnancy (risk of foetal malformations).
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200 mg in 100 ml bottle or bag (2 mg/ml), for IV infusion
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Cryptococcal meningitis, in combination with amphotericin B or flucytosine Child 1 month and over: 12 mg/kg (max. 800 mg) once daily administered over 20 minutes minimum (max. 5 ml/minute) Adult: 1200 mg once daily, administered over 10 minutes minimum (max. 10 ml/minute) Severe oesophageal candidiasis Child 1 month and over: 3 to 6 mg/kg (max. 200 mg) once daily Adult: 200 mg (max. 400 mg) once daily
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Change to oral treatment as soon as possible.
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As in neonates the half-life of fluconazole is prolonged, fluconazole should be administered every 72 hours (neonates < 14 days) or every 48 hours (neonates ≥ 14 days). For cryptococcocal meningitis, when amphotericin B is not available or not tolerated, fluconazole may be administered alone during the induction phase (same doses as the oral route). Do not add any drug in the infusion bottle or bag.
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Below 25 °C. Do not store in a refrigerator.
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1200 mg once daily, administered over 10 minutes minimum (max. 10 ml/minute)
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200 mg (max. 400 mg) once daily
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