Drug reference
Superficial malignant and pre-malignant skin lesions ▶TO THE SKIN USING CREAM ▶Adult: Apply 1–2 times a day for 3–4 weeks (usual duration of initial therapy), apply thinly to the affected area, maximum area of skin 500 cm2 (e.g. 23 cm 6 23 cm) treated at one time, alternative regimens may be used in some settings
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Avoid contact with eyes and mucous membranes. dihydropyrimidine dehydrogenase deficiency . do not apply to bleeding lesions
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→Appendix 1: fluorouracil
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GENERAL SIDE-EFFECTS ▶Common or very common Alopecia. diarrhoea. mucositis. nausea. neutropenia. skin reactions. stomatitis. thrombocytopenia. vomiting ▶Uncommon Dizziness. headache ▶Rare or very rare Abdominal pain. chills. diarrhoea haemorrhagic. fever. leucocytosis. pancytopenia. skin irritation (use a topical corticosteroid for severe discomfort associated with inflammatory reactions). skin ulcer ▶Frequency not known Conjunctival irritation. excessive tearing. keratitis. taste altered
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Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Manufacturers advise avoid (teratogenic).
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Manufacturers advise avoid. l HANDLING AND STORAGE Caution in handling—irritant to tissues.
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There can be variation in the licensing of different medicines containing the same drug. Cream EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and stearyl alcohol), hydroxybenzoates (parabens), polysorbates, propylene glycol ▶Efudix (Mylan) Fluorouracil 50 mg per 1 gram Efudix 5% cream | 40 gram P £32.90 DT = £32.90
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Apply 1–2 times a day for 3–4 weeks (usual
First-line fragment. Read the complete Indications and Dose section above.
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