Drug reference
Maintenance in schizophrenia and other psychoses ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: Test dose 12.5 mg, dose to be administered into the gluteal muscle, then 12.5–100 mg after 4–7 days, then 12.5–100 mg every 14–35 days, adjusted according to response ▶Elderly: Test dose 6.25 mg, dose to be administered into the gluteal muscle, then 12.5–100 mg after 4–7 days, then 12.5–100 mg every 14–35 days, adjusted according to response
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Children. CNS depression. comatose states. marked cerebral atherosclerosis. phaeochromocytoma
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Hypothyroidism. QT-interval prolongation. when transferring from oral to depot therapy, the dose by mouth should be reduced gradually
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→Appendix 1: phenothiazines
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Acute kidney injury. blood disorder. cognitive impairment. epileptiform seizure. headache. hepatic disorders. hyponatraemia. lens opacity. leucocytosis. nasal congestion. oculogyric crisis. oedema. oligomenorrhoea. sexual dysfunction. SIADH. skin pigmentation change. systemic lupus erythematosus (SLE) . temperature regulation disorder. thrombocytopenia. urinary disorders. vision blurred SIDE-EFFECTS, FURTHER INFORMATION Side-effects may persist until the drug has been cleared from its depot site
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Manufacturer advises caution; avoid in hepatic failure.
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Manufacturer advises caution. Avoid in renal failure. Dose adjustments Start with small doses of antipsychotic drugs in severe renal impairment because of increased cerebral sensitivity.
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Treatment requires careful monitoring for optimum effect.
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In general not more than 2–3 mL of oily injection should be administered at any one site. Correct injection technique (including use of z-track technique) and rotation of injection sites are essential. When initiating therapy with sustained-release preparations of conventional antipsychotics, patients should first be given a small test-dose as undesirable side- effects are prolonged.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection EXCIPIENTS: May contain Sesame oil ▶Modecate (Sanofi) Fluphenazine decanoate 25 mg per 1 ml Modecate 25mg/1ml solution for injection ampoules | 10 ampoule P £22.55 DT = £22.55 Fluphenazine decanoate 100 mg per 1 ml Modecate Concentrate 100mg/1ml solution for injection ampoules | 5 ampoule P £43.73 DT = £43.73 eiiii F 401
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Test dose 6.25 mg, dose to be administered
First-line fragment. Read the complete Indications and Dose section above.
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