Drug reference

Flurbiprofen

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1225

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Pain and inflammation in rheumatic disease and other musculoskeletal disorders | Migraine | Postoperative analgesia | Mild to moderate pain ▶BY MOUTH ▶Child 12–17 years: 150–200 mg daily in 2–4 divided doses, then increased to 300 mg daily, dose to be increased only in acute conditions ▶Adult: 150–200 mg daily in 2–4 divided doses, then increased to 300 mg daily, dose to be increased only in acute conditions Dysmenorrhoea ▶BY MOUTH ▶Child 12–17 years: Initially 100 mg, then 50–100 mg every 4–6 hours; maximum 300 mg per day ▶Adult: Initially 100 mg, then 50–100 mg every 4–6 hours; maximum 300 mg per day

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Contra Indications

Active gastro-intestinal bleeding. active gastro-intestinal ulceration. Crohn’s disease (may be exacerbated). history of gastro-intestinal bleeding related to previous NSAID therapy. history of gastro- intestinal perforation related to previous NSAID therapy. history of recurrent gastro-intestinal haemorrhage (two or more distinct episodes). history of recurrent gastro- intestinal ulceration (two or more distinct episodes). severe heart failure. ulcerative colitis (may be exacerbated)

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Cautions

Allergic disorders. cardiac impairment (NSAIDs may impair renal function). cerebrovascular disease. coagulation defects. connective-tissue disorders. dehydration (risk of renal impairment). elderly (risk of serious side-effects and fatalities). heart failure. history of gastro-intestinal disorders. ischaemic heart disease. peripheral arterial disease. risk factors for cardiovascular events. uncontrolled hypertension

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Allergy And Cross Sensitivity

Contra-indicated in patients with a history of hypersensitivity to aspirin or any other NSAID—which includes those in whom attacks of asthma, angioedema, urticaria or rhinitis have been precipitated by aspirin or any other NSAID.

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Safety

Interactions

→Appendix 1: NSAIDs

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Side Effects

Agranulocytosis. angioedema. aplastic anaemia. asthma. bronchospasm. confusion. constipation. Crohn’s disease. depression. diarrhoea. dizziness. drowsiness. dyspnoea. fatigue. fertility decreased female. gastrointestinal discomfort. gastrointestinal disorders. haemolytic anaemia. haemorrhage. hallucination. headache. heart failure. hepatic disorders. hypersensitivity. hypertension. malaise . meningitis aseptic (patients with connective-tissue disorders such as systemic lupus erythematosus may be especially susceptible). nausea. nephritis tubulointerstitial. nephropathy. neutropenia. oedema. optic neuritis. oral ulceration. pancreatitis. paraesthesia. photosensitivity reaction. platelet aggregation inhibition. renal failure (more common in patients with pre-existing renal impairment). respiratory tract reaction. severe cutaneous adverse reactions (SCARs). skin reactions. stroke. thrombocytopenia. tinnitus. vertigo. visual impairment. vomiting SIDE-EFFECTS, FURTHER INFORMATION For information about cardiovascular and gastrointestinal side-effects, and a possible exacerbation of symptoms in asthma, see Non- steroidal anti-inﬂammatory drugs. p. 1193

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Conception And Contraception

Caution—long-term use of some NSAIDs is associated with reduced female fertility, which is reversible on stopping treatment.

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Pregnancy

Avoid unless the potential beneﬁt outweighs Musculoskeletal system the risk. Avoid during the third trimester (risk of closure of fetal ductus arteriosus in utero and possibly persistent pulmonary hypertension of the newborn); onset of labour may be delayed and duration may be increased.

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Breast Feeding

Use with caution during breast-feeding. Small amount present in milk—manufacturer advises avoid.

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Hepatic Impairment

Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment.

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Renal Impairment

Avoid if possible or use with caution. Avoid in severe impairment. Dose adjustments The lowest effective dose should be used for the shortest possible duration. Monitoring In renal impairment monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 21 ▶Flurbiprofen (Non-proprietary) Flurbiprofen 50 mg Flurbiprofen 50mg tablets | 100 tablet P £21.30–£51.81 DT = £47.49 Flurbiprofen 100 mg Flurbiprofen 100mg tablets | 100 tablet P £38.10–£92.64 DT = £84.92

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Dose text by age group

Child 12–17 years

150–200 mg daily in 2–4 divided

First-line fragment. Read the complete Indications and Dose section above.

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Child 12–17 years

Initially 100 mg, then 50–100 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1225

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Flurbiprofen

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1225

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1225

Contra Indications

PDF page 1225

Cautions

PDF page 1225

Allergy And Cross Sensitivity

PDF page 1225

Safety

Interactions

→Appendix 1: NSAIDs

PDF page 1225

Side Effects

PDF page 1225

Conception And Contraception

Caution—long-term use of some NSAIDs is associated with reduced female fertility, which is reversible on stopping treatment.

PDF page 1225

Pregnancy

PDF page 1225

Breast Feeding

Use with caution during breast-feeding. Small amount present in milk—manufacturer advises avoid.

PDF page 1225

Hepatic Impairment

Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment.

PDF page 1225

Renal Impairment

PDF page 1225

Dose and formulations

Medicinal Forms

PDF page 1225

Dose text by age group

Child 12–17 years

150–200 mg daily in 2–4 divided

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1225

Child 12–17 years

Initially 100 mg, then 50–100 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1225

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.