Names and pronunciation
(floo-tic′a-sone) Cutivate
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Drug reference
(floo-tic′a-sone) Cutivate
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Func. class.: Corticosteroid, topical
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Do not confuse: fluticasone/mometasone/fludrocortisone
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ACTION: Crosses cell membrane to attach to receptors to decrease inflam- mation, itching; inhibits multiple inflam- matory cytokines
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USES: Inflammation/itching of corti- costeroid-responsive dermatoses on the skin
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CONTRAINDICATIONS: Hyper- sensitivity to this product or milk protein, status asthmaticus, monotherapy in pri- mary infections, Cushing syndrome, rosa- cea, perioral dermatitis, diabetes mellitus Precautions: Pregnancy, children, breastfeeding, skin infections, skin atrophy
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SIDE EFFECTS INTEG: Burning, pruritus, dermatitis, hypertrichosis, hives, rash, xerosis, irri- tation, hyperpigmentation, miliaria META: Hyperglycemia, glycosuria MISC: HPA axis suppression, Cushing syndrome
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INTERACTIONS Drug/Lab Increase: Blood glucose
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DOSAGE AND ROUTES • Adult: Apply to affected areas bid (cream/ ointment) or daily (lotion) × 4 wk
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Available forms: Lotion, cream 0.05%, ointment 0.005%
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Administer: Topical route • Do not use with occlusive dressings • Cream/ointment/lotion: Apply sparingly in a thin film and rub gently into the cleansed affected area; wash hands, use gloves; avoid use on face, groin, underarms • Reassess treatment after 2 uses
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Assess: • Skin reactions: burning, pruritus, dermatitis
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Evaluate: • Decreasing itching, inflammation on the skin
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: Topical route: • Not to use with occlusive dressings • Cream/ointment/lotion: to apply spar- ingly in a thin film and rub gently into the cleansed affected area; avoid use on face, groin, underarms; wash hands; use gloves • To reassess treatment after each use F
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PHARMACOKINETICS Absorption 5% but variable; half-life 7 hr
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• Adult: Apply to affected areas bid (cream/ ointment) or daily (lotion) × 4 wk
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