Drug reference

Fluvastatin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 237, 238

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Adjunct to diet in primary hypercholesterolaemia or combined (mixed) hyperlipidaemia (types IIa and IIb) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 20–40 mg daily, dose to be taken in the evening, increased if necessary up to 80 mg daily in 2 divided doses, dose to be adjusted at intervals of at least 4 weeks ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 80 mg daily, dose form is not appropriate for initial dose titration Prevention of coronary events after percutaneous coronary intervention ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES continued → ▶Adult: 80 mg daily ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 80 mg daily, dose form is not appropriate for initial dose titration

PDF pages 237, 238

Dose Adjustments

DUE TO INTERACTIONS Cardiovascular system ▶Max. dose 20 mg daily with concomitant elbasvir with grazoprevir.

PDF page 238

National Funding Access Decisions

Scottish Medicines Consortium (SMC) decisions SMC No. 76/04 The Scottish Medicines Consortium has advised (February 2004) that ﬂuvastatin (Lescol ®) is accepted for restricted use for the secondary prevention of coronary events after percutaneous coronary angioplasty; if the patient has previously been receiving another statin, then there is no need to change the statin.

PDF page 238

Safety

Interactions

→Appendix 1: statins

PDF page 238

Side Effects

▶Rare or very rare Angioedema. face oedema. lupus-like syndrome. muscle weakness. sensation abnormal. vasculitis

PDF page 238

Breast Feeding

Manufacturer advises avoid—no information available.

PDF page 238

Renal Impairment

Dose adjustments Manufacturer advises doses above 40 mg daily should be initiated with caution if eGFR less than 30 mL/minute/1.73 m2.

PDF page 238

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Modified-release tablet CAUTIONARY AND ADVISORY LABELS 25 ▶Cadaff XL (Torrent Pharma (UK) Ltd) Fluvastatin (as Fluvastatin sodium) 80 mg Cadaff XL 80mg tablets | 28 tablet P £19.20 DT = £19.20 ▶Dorisin XL (Aspire Pharma Ltd) Fluvastatin (as Fluvastatin sodium) 80 mg Dorisin XL 80mg tablets | 28 tablet P £19.20 DT = £19.20 ▶Lescol XL (Novartis Pharmaceuticals UK Ltd) Fluvastatin (as Fluvastatin sodium) 80 mg Lescol XL 80mg tablets | 28 tablet P £19.20 DT = £19.20 ▶Nandovar XL (Sandoz Ltd) Fluvastatin (as Fluvastatin sodium) 80 mg Nandovar XL 80mg tablets | 28 tablet P £16.32 DT = £19.20 Capsule ▶Fluvastatin (Non-proprietary) Fluvastatin (as Fluvastatin sodium) 20 mg Fluvastatin 20mg capsules | 28 capsule P £6.96 DT = £2.21 Fluvastatin (as Fluvastatin sodium) 40 mg Fluvastatin 40mg capsules | 28 capsule P £7.42 DT = £2.64 eiiii F 214

PDF page 238

Clinical care

Patient And Carer Advice

Patient counselling is advised for ﬂuvastatin tablets/capsules (muscle effects).

PDF page 238

Dose text by age group

Adult

Initially 20–40 mg daily, dose to be taken in the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 237

Adult

80 mg daily, dose form is not appropriate for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 237

Adult

80 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 237

Adult

80 mg daily, dose form is not appropriate for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Fluvastatin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 237, 238

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF pages 237, 238

Dose Adjustments

DUE TO INTERACTIONS Cardiovascular system ▶Max. dose 20 mg daily with concomitant elbasvir with grazoprevir.

PDF page 238

National Funding Access Decisions

PDF page 238

Safety

Interactions

→Appendix 1: statins

PDF page 238

Side Effects

▶Rare or very rare Angioedema. face oedema. lupus-like syndrome. muscle weakness. sensation abnormal. vasculitis

PDF page 238

Breast Feeding

Manufacturer advises avoid—no information available.

PDF page 238

Renal Impairment

Dose adjustments Manufacturer advises doses above 40 mg daily should be initiated with caution if eGFR less than 30 mL/minute/1.73 m2.

PDF page 238

Dose and formulations

Medicinal Forms

PDF page 238

Clinical care

Patient And Carer Advice

Patient counselling is advised for ﬂuvastatin tablets/capsules (muscle effects).

PDF page 238

Dose text by age group

Adult

Initially 20–40 mg daily, dose to be taken in the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 237

Adult

80 mg daily, dose form is not appropriate for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 237

Adult

80 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 237

Adult

80 mg daily, dose form is not appropriate for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 238

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.