Drug Action
Fosamprenavir is a pro-drug of amprenavir.
PDF page 717
Loading InternPractice…
Drug reference
Fosamprenavir is a pro-drug of amprenavir.
PDF page 717
HIV infection in combination with other antiretroviral drugs—with low-dose ritonavir ▶BY MOUTH ▶Adult: 700 mg twice daily DOSE EQUIVALENCE AND CONVERSION ▶700 mg fosamprenavir is equivalent to approximately 600 mg amprenavir.
PDF page 717
Flavours of oral liquid formulations may include grape, bubblegum, or peppermint.
PDF page 717
→Appendix 1: HIV-protease inhibitors
PDF page 717
▶Common or very common Oral paraesthesia SIDE-EFFECTS, FURTHER INFORMATION Rash may occur, usually in the second week of therapy; discontinue permanently if severe rash with systemic or allergic symptoms or, mucosal involvement; if rash mild or moderate, may continue without interruption—usually resolves and may respond to antihistamines.
PDF page 717
Toxicity in animal studies; manufacturer advises use only if potential benefit outweighs risk.
PDF page 717
Manufacturer advises caution. Dose adjustments Manufacturer advises dose reduction to 450 mg twice daily in moderate impairment and 300 mg twice daily in severe impairment.
PDF page 717
In adults, oral suspension should be taken on an empty stomach.
PDF page 717
There can be variation in the licensing of different medicines containing the same drug. Oral suspension EXCIPIENTS: May contain Propylene glycol ▶Telzir (ViiV Healthcare UK Ltd) Fosamprenavir (as Fosamprenavir calcium) 50 mg per 1 ml Telzir 50mg/ml oral suspension | 225 ml P £69.06 Tablet ▶Telzir (ViiV Healthcare UK Ltd) Infection Fosamprenavir (as Fosamprenavir calcium) 700 mg Telzir 700mg tablets | 60 tablet P £258.97 eiiii F 693
PDF page 718
Patients or carers should be given advice on how to administer fosamprenavir oral suspension.
PDF page 717
700 mg twice daily
First-line fragment. Read the complete Indications and Dose section above.
PDF page 717