Names and pronunciation
(fos-am-pren′a-veer) Lexiva, Telzir
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Drug reference
(fos-am-pren′a-veer) Lexiva, Telzir
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Func. class.: Antiretroviral
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Chem. class.: Protease inhibitor
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USES: HIV-1 infection in combination with antiretrovirals, not recommended for initial treatment
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CONTRAINDICATIONS: Hyper- sensitivity to protease inhibitors
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DOSAGE AND ROUTES Therapy-naive patients • Adult: PO 1400 mg bid without ritona- vir or fosamprenavir 1400 mg/day with ritonavir 200 mg/day or fosamprenavir 700 mg bid and ritonavir 100 mg bid • Child >2 yr/adolescent, ≥20 kg: PO 18 mg/kg (max: 700 mg) bid plus ritonavir 3 mg/kg (max: 100 mg) bid; 15 kg to <20 kg: 23 mg/kg bid plus ritonavir 3 mg/kg bid; 11 kg to <15 kg: 30 mg/kg/dose bid plus ritona- vir 3 mg/kg/dose bid; <11 kg: 45 mg/kg/ dose bid plus ritonavir 7 mg/kg/dose bid Protease-experienced patients (PI) • Adult: PO 700 mg bid and ritonavir 100 mg bid • Child/adolescent ≥20 kg: PO 18 mg/kg bid with ritonavir 3 mg/kg bid • Child/adolescent 15 kg to <20 kg: PO 23 mg/kg bid with ritonavir 3 mg/ kg bid • Child/adolescent 11 kg to <15 kg: PO 30 mg/kg bid with ritonavir 3 mg/kg bid • Child/adolescent <11 kg: PO 45 mg/ kg bid with ritonavir 7 mg bid • Infant ≥6 mo, 15 kg to <20 kg: PO susp 23 mg/kg bid with ritonavir 3 mg/ kg bid • Infant ≥6 mo, 11 kg to <15 kg: PO susp 30 mg/kg bid with ritonavir 3 mg/kg bid • Infant ≥6 mo, <11 kg: PO susp 45 mg/ kg bid with ritonavir 7 mg/kg bid Combination with efavirenz • Adult: PO add another 100 mg/day of ritonavir for a total of 300 mg/day when all 3 products given Hepatic dose • Adult: PO (Child-Pugh 5-6) 700 mg bid without ritonavir (treatment-naive pa- tients) or 700 mg bid with ritonavir 100 mg daily (treatment-naive or experienced pa- tients); (Child-Pugh 7-9) 700 mg bid with- out ritonavir (treatment-naive patients) or 450 mg bid with ritonavir 100 mg daily (treatment-naive or experienced patients); (Child-Pugh 10-15) 350 mg bid without ritonavir (treatment-naive patients) or 300 mg bid with ritonavir 100 mg daily
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• Infant ≥6 mo, 15 kg to <20 kg: PO susp 23 mg/kg bid with ritonavir 3 mg/ kg bid
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• Infant ≥6 mo, 11 kg to <15 kg: PO susp 30 mg/kg bid with ritonavir 3 mg/kg bid
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• Infant ≥6 mo, <11 kg: PO susp 45 mg/ kg bid with ritonavir 7 mg/kg bid Combination with efavirenz
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