Names and pronunciation
(gah-lan′tah-meen) Razadyne, Razadyne ER, Reminyl
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Drug reference
(gah-lan′tah-meen) Razadyne, Razadyne ER, Reminyl
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Func. class.: Anti-Alzheimer agent
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Chem. class.: Centrally acting cho- linesterase inhibitor
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USES: Mild to moderate dementia of Alzheimer’s disease, dementia with Lewy bodies
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DOSAGE AND ROUTES • Adult: PO 4 mg bid with morning and evening meals; after 4 wk or more, may increase to 8 mg bid; may increase to 12 mg bid after another 4 wk, usual dose 16-24 mg/day in 2 divided doses; EXT REL 8 mg/day in AM; may increase to 16 mg/day after 4 wk and 24 mg/day after another 4 wk Hepatic dose • Adult: PO Child-Pugh 7-9, max 16 mg/ day; Child-Pugh 10-15, avoid use Renal dose • Adult: PO CCr 10-70 mL/min, max 16 mg/day; CCr <9 mL/min, avoid use
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Available forms: Tabs 4, 8, 12 mg; ext rel caps 8, 16, 24 mg; oral sol 4 mg/mL • To take with food to minimize side effects
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• Adult: PO 4 mg bid with morning and evening meals; after 4 wk or more, may increase to 8 mg bid; may increase to 12 mg bid after another 4 wk, usual dose 16-24 mg/day in 2 divided doses; EXT REL 8 mg/day in AM; may increase to 16 mg/day after 4 wk and 24 mg/day after another 4 wk Hepatic dose
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• Adult: PO Child-Pugh 7-9, max 16 mg/ day; Child-Pugh 10-15, avoid use Renal dose
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• Adult: PO CCr 10-70 mL/min, max 16 mg/day; CCr <9 mL/min, avoid use
PDF page 614