Indications And Dose
Low blood volume in hypovolaemic shock, burns and cardiopulmonary bypass ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 500–1000 mL, use 3.5–4% solution
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Drug reference
Low blood volume in hypovolaemic shock, burns and cardiopulmonary bypass ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 500–1000 mL, use 3.5–4% solution
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Cardiac disease. severe liver disease
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The gelatin is partially degraded. Gelaspan ® contains succinylated gelatin (modified fluid gelatin, average molecular weight 26 500) 40 g, Na+ 151 mmol, K+ 4 mmol, Mg2+ 1 mmol, Cl- 103 mmol, Ca2+ 1 mmol, acetate 24 mmol/litre; Gelofusine ® contains succinylated gelatin (modified fluid gelatin, average molecular weight 30 000) 40 g (4%), Na+ 154 mmol, Cl- 124 mmol/litre; Geloplasma ® contains partially hydrolysed and succinylated gelatin (modified liquid gelatin) (as anhydrous gelatin) 30 g (3%), Na+ 150 mmol, K+ 5 mmol, Mg2+ 1.5mmol, Cl- 100 mmol, lactate 30 mmol/litre; Isoplex ® contains succinylated gelatin (modified fluid gelatin, average molecular weight 30 000) 40g (4%), Na+ 145 mmol, K+ 4 mmol, Mg2+ 0.9 mmol, Cl- 105 mmol, lactate 25mmol/litre; Volplex ® contains succinylated gelatin (modified fluid gelatin, average molecular weight 30 000) 40 g (4%), Na+ 154 mmol, Cl- 125 mmol/litre.
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▶Rare or very rare Chills. dyspnoea. fever. hyperhidrosis. hypersensitivity. hypertension. hypotension. hypoxia. tachycardia. tremor. urticaria. wheezing
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Manufacturer of Geloplasma ® advises avoid at the end of pregnancy.
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Manufacturers advise avoid preparations that contain lactate (risk of impaired lactate metabolism).
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Use with caution in renal impairment.
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▶Urine output should be monitored. Care should be taken to avoid haematocrit concentration from falling below 25–30% and the patient should be monitored for hypersensitivity reactions. ▶Plasma and plasma substitutes are often used in very ill patients whose condition is unstable. Therefore, close monitoring is required and fluid and electrolyte therapy should be adjusted according to the patient’s condition at all times.
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There can be variation in the licensing of different medicines containing the same drug. Infusion ▶Gelaspan (B.Braun Medical Ltd) Gelatin 40 mg per 1 ml Gelaspan 4% infusion 500ml Ecobags | 1 bag P £5.95 (Hospital only) ▶Gelofusine (B.Braun Medical Ltd) Gelatin 40 mg per 1 ml Gelofusine 4% infusion 1litre Ecobags | 1 bag P £9.31 Gelofusine 4% infusion 500ml Ecobags | 1 bag P £4.97 ▶Geloplasma (Fresenius Kabi Ltd) Gelatin 30 mg per 1 ml Geloplasma 3% infusion 500ml Freeflex bags | 20 bag P s (Hospital only) ▶Isoplex (Kent Pharmaceuticals Ltd) Gelatin 40 mg per 1 ml Isoplex 4% infusion 500ml bags | 10 bag P £75.00 (Hospital only) ▶Volplex (Kent Pharmaceuticals Ltd) Gelatin 40 mg per 1 ml Volplex 4% infusion 500ml bags | 10 bag P £47.00 (Hospital only)
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Initially 500–1000 mL, use 3.5–4% solution
First-line fragment. Read the complete Indications and Dose section above.
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