Therapeutic Action
Aminoglycoside antibacterial
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Drug reference
Aminoglycoside antibacterial
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Severe bacterial infections: plague, septicaemia, meningitis, pneumonia, pyelonephritis, postpartum upper genital tract infections, brucellosis, etc., in combination with other antibacterials
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Do not administer to patients with allergy to aminoglycosides. Administer with caution to patients with history of renal, vestibular or auditory problems. Reduce dosage in patients with renal impairment. May cause: irreversible ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade; rarely, allergic reactions. Stop treatment in the event of dizziness, tinnitus or hearing loss (ototoxicity). Do not combine with another aminoglycoside. Avoid or monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers (increased neuromuscular blockage). Pregnancy: administer only if clearly needed (risk of fetal ototoxicity). Breast-feeding: no contra-indication
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10 mg in 1 ml ampoule (10 mg/ml) and 80 mg in 2 ml ampoule (40 mg/ml) for IM or slow IV injection (3 minutes) or IV infusion (30 minutes) in 0.9% sodium chloride or 5% glucose
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Meningitis in young children, in combination with ampicillin or cloxacillin Neonate: 0 to 7 days (< 2 kg): 3 mg/kg once daily by IV injection or infusion 0 to 7 days (≥ 2 kg): 5 mg/kg once daily by IV injection or infusion 8 days to < 1 month: 5 mg/kg once daily by IV injection or infusion Child 1 to 3 months: 2.5 mg/kg every 8 hours by IV injection or infusion Other severe bacterial infections Neonate : as above Child 1 month and over: 4.5 to 7.5 mg/kg once daily Adult: 5 to 6 mg/kg once daily For administration by IV infusion, dilute each dose of gentamicin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.
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Plague: 10 to 14 days Other infections: according to indication and clinical response
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Do not mix with other drugs in the same syringe or infusion.
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– Below 25 °C
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2.5 mg/kg every 8 hours by IV injection or infusion
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as above
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4.5 to 7.5 mg/kg once daily
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5 to 6 mg/kg once daily
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