Names and pronunciation
(jen-ta-mye′sin) Gentak, Garamycin
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Drug reference
(jen-ta-mye′sin) Gentak, Garamycin
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Func. class.: Ophthalmic antiinfective
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Chem. class.: Aminoglycoside
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Do not confuse: gentamicin/clindamycin/tobramycin/ erythromycin/vancomycin
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ACTION: Inhibits protein synthesis by binding of 30s ribosomal subunits, thereby decreasing bacterial replication
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USES: External ocular infections
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CONTRAINDICATIONS: Hyper- sensitivity to this product or amino- glycosides Precautions: Pregnancy, breastfeeding, corneal healing, local redness/irritation
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SIDE EFFECTS EENT: Burning, hypersensitivity, stinging, blurred vision, hyperemia, corneal ulcers
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DOSAGE AND ROUTES Ophthalmic (solution) • Adult/adolescent/child ≥1 mo: SOL 1-2 drops in affected eye(s) every 4 hr while awake × 2 days, then every 4 hr; severe infections ≤2 drops every 1 hr • Ointment: apply a small amount (½ in) to lower conjunctival sac bid or tid
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Available forms: Ophthalmic ointment, ophthalmic solution 0.3%
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Administer: Ophthalmic route • Commercially available ophthalmic solu- tions are not for injection subconjunctivally or into the anterior chamber of the eye • Apply topically to the eye, taking care to avoid contamination • Do not touch the tip of the dropper to the eye, fingertips, or other surface; wash hands before use • Apply pressure to lacrimal sac for 1 G min after instillation • To apply the ointment, pull down gently on lower eyelid and apply a thin film of the ointment
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Assess: • Allergic reaction: hypersensitivity, dis- continue product
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Evaluate: • Therapeutic response: decreased oph- thalmic infection
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: Ophthalmic route • To apply topically to the eye, taking care to avoid contamination; for ophthalmic use only • Not to touch the tip of the dropper to the eye, fingertips, or other surface; to wash hands before use • To apply pressure to lacrimal sac for 1 min after instillation • To apply the ointment by pulling down gently on lower eyelid and applying a thin film of the ointment
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PHARMACOKINETICS Unknown
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• Adult/adolescent/child ≥1 mo: SOL 1-2 drops in affected eye(s) every 4 hr while awake × 2 days, then every 4 hr; severe infections ≤2 drops every 1 hr
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