Drug Action
Glatiramer is an immunomodulating drug comprising synthetic polypeptides.
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Drug reference
Glatiramer is an immunomodulating drug comprising synthetic polypeptides.
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Multiple sclerosis [relapsing-remitting] (initiated under specialist supervision) ▶BY SUBCUTANEOUS INJECTION ▶Adult: 20 mg once daily, alternatively 40 mg 3 times a week, doses to be separated by an interval of at least 48 hours
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Cardiac disorders
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NICE decisions ▶Beta interferons and glatiramer acetate for treating multiple sclerosis (June 2018) NICE TA527 Glatiramer acetate (Copaxone ®) is recommended as an option for treating multiple sclerosis, only if: Immune system and malignant disease . the patient has relapsing-remitting multiple sclerosis, and . the manufacturer provides it according to the commercial arrangement.Patients whose treatment was started within the NHS before this guidance was published should have the option to continue treatment, without change to their funding arrangements, until they and their NHS clinician consider it appropriate to stop. www.nice.org.uk/guidance/ta527 Scottish Medicines Consortium (SMC) decisions SMC No. 1108/15 The Scottish Medicines Consortium has advised (December 2015) that glatiramer acetate (Copaxone ®) is accepted for use within NHS Scotland for the treatment of relapsing forms of multiple sclerosis. NHS restrictions NHS England Clinical Commissioning Policy NHS England (May 2014) has provided guidance on the use of glatiramer acetate for the treatment of multiple sclerosis in England. An NHS England Clinical Commissioning Policy outlines the funding arrangements and the criteria for initiating and discontinuing this treatment option, see www.england. nhs.uk/commissioning/spec-services/npc-crg/group-d/d04.
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▶Common or very common Anxiety. appetite decreased. arrhythmias. asthenia. chest pain. chills. constipation. cough. depression. dyspepsia. dysphagia. dyspnoea (may occur within minutes of injection). ear disorder. eye disorders. fever. gastrointestinal disorders. headaches. hyperhidrosis. hypersensitivity. increased risk of infection . joint disorders. local reaction. lymphadenopathy. nausea. neoplasms. neuromuscular dysfunction. oedema . oral disorders. pain. palpitations. rhinitis seasonal. skin reactions. speech disorder. syncope. taste altered. tremor . urinary disorders. vasodilation. vision disorders. vomiting. weight increased ▶Uncommon Abnormal dreams. abscess. alcohol intolerance. angioedema. apnoea. arthritis. breast engorgement. burping. cataract. choking sensation. cholelithiasis. cognitive disorder. confusion. cyst. dry eye . dysgraphia. dyslexia. erythema nodosum. goitre. gout. haemorrhage. hallucination. hangover. hepatic disorders . hostility. hyperlipidaemia. hyperthyroidism. hypothermia. immediate post-injection reaction. inflammation. injection site necrosis. leucocytosis. leucopenia. mood altered. movement disorders. mucous membrane disorder. muscle atrophy. nephrolithiasis. nerve disorders. paralysis. pelvic prolapse. personality disorder. post vaccination syndrome. prostatic disorder. respiratory disorders. seizure. sexual dysfunction. skin nodule. splenomegaly. stupor. suicide attempt. testicular disorder. thrombocytopenia. urinary tract disorder. urine abnormal. varicose veins. vulvovaginal disorder
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Manufacturer advises avoid—no information available.
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Manufacturer advises caution—no information available.
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No information available— manufacturer advises caution.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Brabio (Mylan) Glatiramer acetate 20 mg per 1 ml Brabio 20mg/1ml solution for injection pre-filled syringes | 28 pre-filled disposable injection P £462.56 DT = £513.95 Glatiramer acetate 40 mg per 1 ml Brabio 40mg/1ml solution for injection pre-filled syringes | 12 pre-filled disposable injection P £462.56 DT = £513.95 ▶Copaxone (Teva UK Ltd) Glatiramer acetate 20 mg per 1 ml Copaxone 20mg/1ml solution for injection pre-filled syringes | 28 pre-filled disposable injection P £513.95 DT = £513.95 Glatiramer acetate 40 mg per 1 ml Copaxone 40mg/1ml solution for injection pre-filled syringes | 12 pre-filled disposable injection P £513.95 DT = £513.95 IMMUNOSUPPRESSANTS › IMMUNOMODULATING DRUGS
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20 mg once daily, alternatively 40 mg 3 times a
First-line fragment. Read the complete Indications and Dose section above.
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