Therapeutic Action
Vasodilator, antianginal
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Drug reference
Vasodilator, antianginal
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Short-term prophylaxis and treatment of acute angina Adjunctive therapy in acute heart failure (acute pulmonary oedema)
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Do not administer to patients with obstructive cardiomyopathy, hypotension, shock, severe anaemia, intracranial hypertension or neurologic injury. May cause: orthostatic hypotension (especially in older patients), headache, nausea, flushing of the face, haemolytic anaemia in patients with G6PD deficiency; severe hypotension with risk of circulatory collapse in the event of overdose. Avoid combination or use the lowest effective dose in patients taking another nitrate derivative, a vasodilator, a diuretic or an antihypertensive drug (enhances hypotensive effects), and in older patients. Do not combine with sildenafil or other drugs used for erectile dysfunction (risk of severe hypotension, syncope and acute coronary syndrome). Pregnancy: not recommended (safety is not established) Breast-feeding: not recommended (safety is not established)
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0.5 mg sublingual tablet
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Short-term prophylaxis of acute angina Adult: 0.5 to 1 mg sublingually taken 5 to 10 minutes before a precipitating event (physical exertion, stress, etc.) Treatment of acute angina Adult: 0.5 to 1 mg sublingually, to be repeated 1 to 3 times at 3-4 minute intervals Adjunctive therapy in acute heart failure (acute pulmonary oedema) Adult: 0.5 mg sublingually, to be repeated 1 to 2 times at 5 minute intervals if necessary. The objective is to lower the systolic pressure to 120-150 mmHg and the diastolic pressure to under 110 mmHg. Do not exceed 3 mg daily.
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According to clinical response
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Antianginal effect appears within less than 5 minutes and persists for less than 1 hour. Tolerance to nitrates develops with prolonged use and can be overcome by short periods of nitrate withdrawal, and not by dose escalation. Sustained-release formulations are used for the long-term management of acute angina and the treatment of heart failure.
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- - Below 25 °C, preferably in airtight glass container
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0.5 to 1 mg sublingually taken 5 to 10 minutes before a precipitating event (physical exertion, stress, etc.)
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0.5 to 1 mg sublingually, to be repeated 1 to 3 times at 3-4 minute intervals
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0.5 mg sublingually, to be repeated 1 to 2 times at 5 minute intervals if necessary. The objective is to lower the systolic pressure to 120-150 mmHg and the diastolic pressure to under
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