Therapeutic Action
Antifungal
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Drug reference
Antifungal
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Dermatophyte infections of the scalp (scalp ringworm) Dermatophyte infections of the skin and folds, in the event of extended lesions or if the topical treatment has failed
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Do not administer to patients with hepatic impairment, lupus erythematous, porphyria (may trigger attacks of acute porphyria). May cause: gastrointestinal disturbances, headache, skin reactions (eruption, urticaria, etc.); photosensitivity (protect exposed skin from sun exposure). In women, use a non-hormonal contraception or injectable medroxyprogesterone during treatment and up to one month after the end of treatment. Monitor patients taking warfarin (anticoagulant effect decreased). Avoid alcohol during treatment (antabuse effect). Pregnancy and breast-feeding: CONTRA-INDICATED. Apply a topical treatment (miconazole 2% cream or Whitfield ointment) in order to limit the lesions until it is possible to use griseofulvin.
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125 mg and 500 mg tablets
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Child 1 to 12 years: 10 to 20 mg/kg once daily (max. 500 mg daily) Child 12 years and over and adult: 500 mg once daily; 1 g once daily in severe infections Age Weight 125 mg tablet 500 mg tablet 1 to < 2 years 10 to < 13 kg 1 tab ¼ tab 2 to < 7 years 13 to < 24 kg 2 tab ½ tab 7 to < 12 years 24 to < 35 kg 4 tab 1 tab ≥ 12 years and adult ≥ 35 kg 4 to 8 tab 1 to 2 tab
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Scalp: 6 weeks minimum Skin and folds: 4 to 6 weeks
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Take with meals. For young children, crush the tablet and mix it with a liquid.
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Below 25 °C
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500 mg once daily; 1 g once daily in severe infections
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