Therapeutic Action
Antipsychotic
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Drug reference
Antipsychotic
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Acute confusional state (delirium) and acute alcohol intoxication Agitation or aggressive behaviour in patients with acute or chronic psychosis, in combination with promethazine
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Do not administer to patients with cardiac disorders (cardiac failure, recent myocardial infarction, conduction disorders, bradycardia, etc.), dementia (e.g. Alzheimer's disease), Parkinson's disease and history of neuroleptic malignant syndrome. Administer with caution and carefully monitor use in older patients and patients with hypokalaemia, hypotension, hyperthyroidism, renal or hepatic impairment, history of seizures. May cause: drowsiness, extrapyramidal syndrome, dyskinesia, anticholinergic effects (constipation, dry mouth), sexual dysfunction, QT-prolongation, ventricular arrhythmia, orthostatic hypotension; neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation. Avoid or monitor combination with: central nervous system depressants (opioid analgesics, sedatives, H1 antihistamines, etc.); fluoxetine, paroxetine, sertraline, ritonavir (increased plasma concentrations of haloperidol); carbamazepine, rifampicin, phenobarbital, phenytoin (decreased plasma concentrations of haloperidol); antihypertensive drugs (risk of hypotension); drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine, pentamidine, quinine, etc.). Keep the patient in the supine position for 30 minutes after injection (risk of orthostatic hypotension): Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, administer at the lowest effective dose. Observe the neonate the first few days (risk of agitation, tremors, hypertonia/hypotonia, respiratory difficulties, sleeping disorders, etc.) if the mother was under rd treatment in the 3 trimester. Breast-feeding: if absolutely necessary, do not exceed 10 mg daily.
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5 mg in 1 ml ampoule (5 mg/ml) for IM injection
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Acute confusional state (delirium) and acute alcohol intoxication Adult: 0.5 to 1 mg, to be repeated after 30 to 60 minutes if necessary. If needed, administer additional doses every 4 hours (max. 5 mg) for 7 days max. Agitation or aggressive behaviour in patients with acute or chronic psychosis, with promethazine Adult: 5 mg, to be repeated after 30 minutes if necessary Change to oral treatment as soon as possible. Reduce the dose by half in older patients (max. 5 mg daily).
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Haloperidol decanoate is a long-acting form used as maintenance therapy of chronic psychotic disorders after stablisation with oral treatment.
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– Below 25 °C
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0.5 to 1 mg, to be repeated after 30 to 60 minutes if necessary. If needed, administer additional doses every 4 hours (max. 5 mg) for 7 days max.
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5 mg, to be repeated after 30 minutes if necessary
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