Names and pronunciation
HepaGam B, HyperHEP B S/D, Nabi-HB
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Drug reference
HepaGam B, HyperHEP B S/D, Nabi-HB
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Func. class.: Immune globulin
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USES: Prevention of hepatitis B virus in exposed patients, including passive immunity in neonates born to HBsAg- positive mother, prevention of hepatitis B recurrence after liver transplant in HBsAg-positive patients
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DOSAGE AND ROUTES Hepatitis B exposure in high-risk patients • Adult/child: IM 0.06 mL/kg (usual 3-5 mL) within 7 days of exposure; re- peat 28 days after exposure if patient wishes to not receive hepatitis B vaccine Neonates born to hepatitis B surface-antigen–positive persons • Neonate: IM 0.5 mL within 12 hr of birth Prevention of hepatitis B infection recurrence after liver transplant • Adult: IV (HepaGam B only) 20,000 international units concurrent with graft- ing transplanted liver, then 20,000 inter- national units/day on days 1-7, then 20,000 international units q2wk starting on day 14, then 20,000 international units/mo starting with month 4
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Available forms: Injection: 1-, 5-mL vials; 0.5-mL neonatal single-dose syringe; 1-mL single-dose syringe See Appendix B
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• Neonate: IM 0.5 mL within 12 hr of birth Prevention of hepatitis B infection recurrence after liver transplant
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