Indications And Dose
ENGERIX B ® Immunisation against hepatitis B infection ▶BY INTRAMUSCULAR INJECTION ▶Child 1 month–15 years: 10 micrograms for 1 dose, then 10 micrograms after 1 month for 1 dose, followed by 10 micrograms after 5 months for 1 dose, deltoid muscle is preferred site of injection in older children; anterolateral thigh is preferred site in infants and young children; not to be injected into the buttock (vaccine efficacy reduced) ▶Child 16–17 years: 20 micrograms for 1 dose, then 20 micrograms after 1 month for 1 dose, followed by 20 micrograms after 5 months for 1 dose, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) ▶Adult: 20 micrograms for 1 dose, then 20 micrograms Vaccines after 1 month for 1 dose, followed by 20 micrograms after 5 months for 1 dose, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) Immunisation against hepatitis B infection (accelerated schedule) ▶BY INTRAMUSCULAR INJECTION ▶Neonate: 10 micrograms every month for 3 doses, followed by 10 micrograms after 10 months for 1 dose, anterolateral thigh is preferred site in neonates; not to be injected into the buttock (vaccine efficacy reduced), this dose should not be given to neonates born to hepatitis B surface antigen positive mother. ▶Child 1 month–15 years: 10 micrograms every month for 3 doses, followed by 10 micrograms after 10 months for 1 dose, deltoid muscle is preferred site of injection in older children; anterolateral thigh is preferred site in infants and young children; not to be injected into the buttock (vaccine efficacy reduced) ▶Child 16–17 years: 20 micrograms every month for 3 doses, followed by 20 micrograms after 10 months for 1 dose, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) ▶Adult: 20 micrograms every month for 3 doses, followed by 20 micrograms after 10 months for 1 dose, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) Immunisation against hepatitis B infection, alternative accelerated schedule ▶BY INTRAMUSCULAR INJECTION ▶Child 11–15 years: 20 micrograms for 1 dose, followed by 20 micrograms after 6 months, this schedule is not suitable if high risk of infection between doses or if compliance with second dose uncertain, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) Immunisation against hepatitis B infection (accelerated schedule in exceptional cases, e.g. for travellers departing within 1 month) ▶BY INTRAMUSCULAR INJECTION ▶Adult: 20 micrograms for 1 dose, then 20 micrograms after 7 days for 1 dose, followed by 20 micrograms after 14 days for 1 dose, followed by 20 micrograms for 1 dose, to be given 12 months after the first dose, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) continued → Immunisation against hepatitis B infection (in renal insufficiency, including haemodialysis patients) ▶BY INTRAMUSCULAR INJECTION ▶Child 1 month–15 years: 10 micrograms every month for 2 doses, followed by 10 micrograms after 5 months for 1 dose, immunisation schedule and booster doses may need to be adjusted in those with low antibody concentration, deltoid muscle is preferred site of injection in older children; anterolateral thigh is preferred site in infants and young children; not to be injected into the buttock (vaccine efficacy reduced) ▶Child 16–17 years: 40 micrograms every month for 3 doses, followed by 40 micrograms after 4 months for 1 dose, immunisation schedule and booster doses may need to be adjusted in those with low antibody concentration, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) ▶Adult: 40 micrograms every month for 3 doses, followed by 40 micrograms after 4 months for 1 dose, immunisation schedule and booster doses may need to Vaccines be adjusted in those with low antibody concentration, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) Immunisation against hepatitis B infection (in renal insufficiency, including haemodialysis patients (accelerated schedule)) ▶BY INTRAMUSCULAR INJECTION ▶Child 1 month–15 years: 10 micrograms every month for 3 doses, followed by 10 micrograms after 10 months for 1 dose, immunisation schedule and booster doses may need to be adjusted in those with low antibody concentration, deltoid muscle is preferred site of injection in older children; anterolateral thigh is preferred site in infants and young children; not to be injected into the buttock (vaccine efficacy reduced) FENDRIX ® Immunisation against hepatitis B infection in renal insufficiency (including pre-haemodialysis and haemodialysis patients) ▶BY INTRAMUSCULAR INJECTION ▶Child 15–17 years: 20 micrograms every month for 3 doses, followed by 20 micrograms after 4 months for 1 dose, immunisation schedule and booster doses may need to be adjusted in those with low antibody concentration, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) ▶Adult: 20 micrograms every month for 3 doses, followed by 20 micrograms after 4 months for 1 dose, immunisation schedule and booster doses may need to be adjusted in those with low antibody concentration, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) HBVAXPRO ® Immunisation against hepatitis B infection ▶BY INTRAMUSCULAR INJECTION ▶Neonate: 5 micrograms for 1 dose, followed by 5 micrograms after 1 month for 1 dose, then 5 micrograms after 5 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, anterolateral thigh is preferred site in neonates; not to be injected into the buttock (vaccine efficacy reduced), dose not to be used for neonate born to hepatitis B surface antigen positive mother. ▶Child 1 month–15 years: 5 micrograms for 1 dose, followed by 5 micrograms after 1 month for 1 dose, then 5 micrograms after 5 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, deltoid muscle is preferred site of injection in adults and older children; anterolateral thigh is preferred site in infants; not to be injected into the buttock (vaccine efficacy reduced) ▶Child 16–17 years: 10 micrograms for 1 dose, followed by 10 micrograms after 1 month for 1 dose, followed by 10 micrograms after 5 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, deltoid muscle is preferred site of injection in adults and older children; not to be injected into the buttock (vaccine efficacy reduced) ▶Adult: 10 micrograms for 1 dose, followed by 10 micrograms after 1 month for 1 dose, followed by 10 micrograms after 5 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, deltoid muscle is preferred site of injection in adults and older children; not to be injected into the buttock (vaccine efficacy reduced) Immunisation against hepatitis B infection (accelerated schedule) ▶BY INTRAMUSCULAR INJECTION ▶Neonate: 5 micrograms every month for 3 doses, followed by 5 micrograms after 10 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, anterolateral thigh is preferred site in neonates; not to be injected into the buttock (vaccine efficacy reduced), dose not to be used for neonate born to hepatitis B surface antigen positive mother. ▶Child 1 month–15 years: 5 micrograms every month for 3 doses, followed by 5 micrograms after 10 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, deltoid muscle is preferred site of injection in older children; anterolateral thigh is preferred site in infants; not to be injected into the buttock (vaccine efficacy reduced) ▶Child 16–17 years: 10 micrograms every month for 3 doses, followed by 10 micrograms after 10 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, deltoid muscle is preferred site of injection in older children; not to be injected into the buttock (vaccine efficacy reduced) ▶Adult: 10 micrograms every month for 3 doses, followed by 10 micrograms after 10 months for 1 dose, booster doses may be required in immunocompromised patients with low antibody concentration, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced) Neonate born to hepatitis B surface antigen-positive mother ▶BY INTRAMUSCULAR INJECTION ▶Neonate: 5 micrograms every month for 3 doses, first dose given at birth with hepatitis B immunoglobulin injection (separate site), followed by 5 micrograms after 10 months for 1 dose, anterolateral thigh is preferred site in neonates; not to be injected into the buttock (vaccine efficacy reduced). Chronic haemodialysis patients ▶BY INTRAMUSCULAR INJECTION ▶Child 16–17 years: 40 micrograms every month for 2 doses, followed by 40 micrograms after 5 months for 1 dose, booster doses may be required in those with low antibody concentration, deltoid muscle is preferred site of injection in older children; not to be injected into the buttock (vaccine efficacy reduced) ▶Adult: 40 micrograms every month for 2 doses, followed by 40 micrograms after 5 months for 1 dose, booster doses may be required in those with low antibody concentration, deltoid muscle is preferred site of injection; not to be injected into the buttock (vaccine efficacy reduced)
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