Therapeutic Action
Thiazide diuretic
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Drug reference
Thiazide diuretic
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Hypertension Oedema associated with renal, hepatic or congestive heart failure
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Do not administer to patients with severe renal failure. Administer with caution in patients with hypokalaemia, hyponatraemia and in elderly patients. May cause: dehydration, hypotension, hypokalaemia, hyponatraemia; gastrointestinal disturbances, headache, dizziness, skin rash, impotence, photosensitivity. Avoid or monitor combination with NSAIDs (risk of renal impairment); lithium (increased plasma concentrations of lithium). Monitor combination with: drugs that provoke hypotension (e.g. haloperidol, amitriptyline) and antihypertensive drugs (risk of hypotension); potassium-depleting drugs (e.g. corticosteriods, laxatives, amphotericin B), sodium-depleting drugs (e.g. SSRI, carbamazepine), drugs enhancing hypercalcemic effect (e.g. calcium, ergocalciferol); oral antidiabetics and insulin (risk of hyperglycaemia). Pregnancy: CONTRA-INDICATED Breast-feeding: CONTRA-INDICATED
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12.5 mg and 25 mg tablets
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Hypertension Adult: 12.5 to 25 mg once daily in the morning (max. 25 mg daily) Oedema associated with renal, hepatic or congestive heart failure Adult: 25 mg once daily in the morning or 25 mg 2 times daily (max. 100 mg daily)
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According to clinical response
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A potassium-rich diet (dates, bananas, mangos, oranges, tomatoes, etc.) is recommended during treatment. If potassium level is < 3.5 mmol/litre, administer a sustained-released potassium supplement. Diuretics are not indicated in the treatment of nutritional oedema.
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- Below 25 °C
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12.5 to 25 mg once daily in the morning (max. 25 mg daily)
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25 mg once daily in the morning or 25 mg 2 times daily (max. 100 mg daily)
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