Drug reference

Hydromorphone hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 505, 506

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Severe pain in cancer ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 1.3 mg every 4 hours, dose to be Nervous system increased if necessary according to severity of pain ▶Adult: 1.3 mg every 4 hours, dose to be increased if necessary according to severity of pain ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Child 12–17 years: 4 mg every 12 hours, dose to be increased if necessary according to severity of pain ▶Adult: 4 mg every 12 hours, dose to be increased if necessary according to severity of pain

PDF page 505

Contra Indications

Acute abdomen

PDF page 505

Cautions

Pancreatitis. toxic psychosis

PDF page 505

Safety

Interactions

→Appendix 1: opioids

PDF page 505

Side Effects

▶Common or very common Abdominal pain. anxiety. appetite decreased. asthenia. sleep disorders ▶Uncommon Depression. diarrhoea. dyspnoea. erectile dysfunction. malaise. movement disorders. paraesthesia. peripheral oedema. taste altered. tremor ▶Frequency not known Hyperalgesia. paralytic ileus. seizure . withdrawal syndrome neonatal

PDF page 505

Breast Feeding

Avoid—no information available.

PDF page 505

Hepatic Impairment

Manufacturer advises avoid.

PDF page 505

Renal Impairment

Avoid use or reduce dose; opioid effects increased and prolonged and increased cerebral sensitivity occurs.

PDF page 505

Dose and formulations

Directions For Administration

For immediate-release capsules, swallow whole capsule or sprinkle contents on soft food. For modiﬁed-release capsules, swallow whole or open capsule and sprinkle contents on soft cold food (swallow the pellets within the capsule whole; do not crush or chew).

PDF page 505

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Modified-release capsule CAUTIONARY AND ADVISORY LABELS 2 ▶Palladone SR (Napp Pharmaceuticals Ltd) Hydromorphone hydrochloride 2 mg Palladone SR 2mg capsules | 56 capsule P £20.98 DT = £20.98 b Hydromorphone hydrochloride 4 mg Palladone SR 4mg capsules | 56 capsule P £28.75 DT = £28.75 b Hydromorphone hydrochloride 8 mg Palladone SR 8mg capsules | 56 capsule P £56.08 DT = £56.08 b Hydromorphone hydrochloride 16 mg Palladone SR 16mg capsules | 56 capsule P £106.53 DT = £106.53 b Hydromorphone hydrochloride 24 mg Palladone SR 24mg capsules | 56 capsule P £159.82 DT = £159.82 b Capsule CAUTIONARY AND ADVISORY LABELS 2 ▶Palladone (Napp Pharmaceuticals Ltd) Hydromorphone hydrochloride 1.3 mg Palladone 1.3mg capsules | 56 capsule P £8.82 DT = £8.82 b Hydromorphone hydrochloride 2.6 mg Palladone 2.6mg capsules | 56 capsule P £17.64 DT = £17.64 b eiiii F 467

PDF pages 505, 506

Clinical care

Patient And Carer Advice

Patients or carers should be given advice on how to administer hydromorphone hydrochloride capsules and modiﬁed-release capsules.

PDF page 505

Dose text by age group

Child 12–17 years

1.3 mg every 4 hours, dose to be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Adult

1.3 mg every 4 hours, dose to be increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Child 12–17 years

4 mg every 12 hours, dose to be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Adult

4 mg every 12 hours, dose to be increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Hydromorphone hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 505, 506

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 505

Contra Indications

Acute abdomen

PDF page 505

Cautions

Pancreatitis. toxic psychosis

PDF page 505

Safety

Interactions

→Appendix 1: opioids

PDF page 505

Side Effects

PDF page 505

Breast Feeding

Avoid—no information available.

PDF page 505

Hepatic Impairment

Manufacturer advises avoid.

PDF page 505

Renal Impairment

Avoid use or reduce dose; opioid effects increased and prolonged and increased cerebral sensitivity occurs.

PDF page 505

Dose and formulations

Directions For Administration

PDF page 505

Medicinal Forms

PDF pages 505, 506

Clinical care

Patient And Carer Advice

Patients or carers should be given advice on how to administer hydromorphone hydrochloride capsules and modiﬁed-release capsules.

PDF page 505

Dose text by age group

Child 12–17 years

1.3 mg every 4 hours, dose to be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Adult

1.3 mg every 4 hours, dose to be increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Child 12–17 years

4 mg every 12 hours, dose to be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Adult

4 mg every 12 hours, dose to be increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 505

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.