Therapeutic Action
Sedating H1 antihistamine
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Drug reference
Sedating H1 antihistamine
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Moderate anxiety Insomnia
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Do not administer to patients with closed-angle glaucoma, prostate disorders, dementia, history of QT interval prolongation. Do not combine with drugs that prolong the QT interval (amiodarone, co-artemether, erythromycin, fluconazole, haloperidol, mefloquine, pentamidine, quinine, etc.). Administer with caution (max. 50 mg daily) and monitor use in older patients or patients with hepatic impairment or severe renal impairment. May cause: drowsiness (caution when driving/operating machinery), headache, dizziness; anticholinergic effects (dry mouth, constipation, blurred vision, tachycardia, disorders of micturition); rarely: seizures, QT interval prolongation, allergic reactions. Administer with caution and monitor combination with: central nervous system depressants (opioid analgesics, sedatives, etc.); anticholinergic drugs (atropine, amitriptyline, chlorpromazine, promethazine, etc.). Avoid alcohol during treatment (increased risk of adverse effects). Pregnancy and breast-feeding: avoid
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25 mg tablet
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Moderate anxiety Adult: 25 to 50 mg 2 times daily (max. 100 mg daily) Reduce the dose by half in older patients. Insomnia Adult: 25 mg once daily at bedtime
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Moderate anxiety: as short as possible (max. 2 weeks) Insomnia: 7 to 10 days
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– – Below 25 °C
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25 to 50 mg 2 times daily (max. 100 mg daily)
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25 mg once daily at bedtime
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