Drug Action
Idebenone is a nootropic and antioxidant that is thought to act by restoring cellular ATP generation, thereby reactivating retinal ganglion cells.
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Drug reference
Idebenone is a nootropic and antioxidant that is thought to act by restoring cellular ATP generation, thereby reactivating retinal ganglion cells.
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Leber’s Hereditary Optic Neuropathy (initiated by a specialist) ▶BY MOUTH ▶Adult: 300 mg 3 times a day
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Scottish Medicines Consortium (SMC) decisions The Scottish Medicines Consortium has advised (May 2017) that idebenone (Raxone ®) is accepted for restricted use within NHS Scotland for the treatment of visual impairment in patients with Leber’s Hereditary Optic Neuropathy (LHON) who are not yet blind i.e. they do not meet the UK criteria to be registered as severely sight impaired. This advice is contingent upon the continuing availability of the Patient Access Scheme in NHS Scotland or a list price that is equivalent or lower.
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▶Common or very common Cough. diarrhoea. increased risk of infection. pain ▶Frequency not known Agranulocytosis. anaemia. anxiety. appetite decreased. azotaemia. delirium. dizziness. dyspepsia. hallucination. headache. hepatitis. leucopenia . malaise. movement disorders. nausea. neutropenia. poriomania. seizure. skin reactions. stupor. thrombocytopenia. urine discolouration. vomiting SIDE-EFFECTS, FURTHER INFORMATION The metabolites of idebenone may cause red-brown discolouration of the urine. This effect is harmless, but the manufacturer advises caution as this may mask colour changes due to other causes (e.g. renal or blood disorders).
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Manufacturer advises avoid unless potential benefit outweighs risk—no information available.
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Manufacturer advises avoid—present in milk in animal studies.
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Manufacturer advises caution (no information available).
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Manufacturer advises use with caution—no information available.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 14, 21 ▶Raxone (Chiesi Ltd) A Idebenone 150 mg Raxone 150mg tablets | 180 tablet P £6,364.00 DT = £6,364.00 6.4 Vitreomacular traction RECOMBINANT PROTEOLYTIC ENZYMES Eye
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300 mg 3 times a day
First-line fragment. Read the complete Indications and Dose section above.
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