Drug reference
Imiglucerase is an enzyme produced by recombinant DNA technology that is administered as enzyme replacement therapy for non-neurological manifestations of type I or type III Gaucher’s disease, a familial disorder affecting principally the liver, spleen, bone marrow, and lymph nodes.
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Non-neurological manifestations of type I Gaucher’s disease (specialist use only) | Non-neurological manifestations of type III Gaucher’s disease (specialist use only) ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 60 units/kg every 2 weeks; maintenance, adjusted according to response, doses as low as 15 units/kg once every 2 weeks may improve haematological parameters and organomegaly
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▶Common or very common Angioedema. cough. dyspnoea. hypersensitivity. skin reactions ▶Uncommon Abdominal cramps. arthralgia. back pain. chest discomfort. chills. cyanosis. diarrhoea. dizziness. fatigue. fever. flushing. headache. hypotension. nausea. paraesthesia. tachycardia. vomiting
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Manufacturer advises use with caution— limited information available.
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No information available.
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▶Monitor for immunoglobulin G (IgG) antibodies to imiglucerase. ▶When stabilised, monitor all parameters and response to treatment at intervals of 6–12 months.
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For intravenous infusion (Cerezyme ®), give intermittently in Sodium chloride 0.9%; initially reconstitute with water for injections (200 units in 5.1 mL, 400 units in 10.2 mL) to give 40 units/mL solution; dilute requisite dose with infusion fluid to a final volume of 100–200 mL and give initial dose at a rate not exceeding 0.5 units/kg/minute, subsequent doses to be given at a rate not exceeding 1 unit/kg/minute; administer within 3 hours after reconstitution.
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There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ELECTROLYTES: May contain Sodium ▶Cerezyme (Genzyme Therapeutics Ltd) Imiglucerase 400 unit Cerezyme 400unit powder for solution for infusion vials | 1 vial P £1,071.29 (Hospital only)
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Initially 60 units/kg every 2 weeks;
First-line fragment. Read the complete Indications and Dose section above.
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