Names and pronunciation
Bay Gam 15%, Flebogamma 5%, Flebogamma DIF 5%, Gammagard 10%, Gammaked, Gammaplex, Gamunex 10%, Privigen 10%, Vivaglobin, Hizentra
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Drug reference
Bay Gam 15%, Flebogamma 5%, Flebogamma DIF 5%, Gammagard 10%, Gammaked, Gammaplex, Gamunex 10%, Privigen 10%, Vivaglobin, Hizentra
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Func. class.: Immune serum
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Chem. class.: IgG
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USES: Replacement for primary and secondary hormonal immunodeficiency syndrome; B-cell chronic lymphocytic leukemia; Kawasaki syndrome; bone marrow transplantation; pediatric HIV infection; agammaglobulinemia; hepatitis A, B exposure; measles exposure; mea- sles vaccine complications; purpura; rubella exposure; chickenpox exposure; chronic inflammatory demyelinating polyneuropathy, multifocal motor neu- ropathy, MS, RA, myasthenia gravis
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CONTRAINDICATIONS: Hyper- sensitivity, coagulopathy, hemophilia, IgA deficiency, thrombocytopenia, fructose intolerance
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DOSAGE AND ROUTES Immune globulin IM (IMIG, IGIM) Hepatitis A prophylaxis • Adult/geriatric/adolescent/child/infant (unlabeled): IM 0.02 mL/kg for those who have not received hepatitis A vaccine and have been exposed during the prior 2 wk Measles prophylaxis (exposed during prior 6 days) • Adult: IM 0.25 mL/kg (immunocom- petent) • Child (unlabeled): IM 0.5 mL/kg as a single dose, max 15 mL (immunocom- promised) Varicella prophylaxis • Adult: IM 0.6-1.2 mL/kg as soon as possible and if varicella-zoster immune globulin is not available Rubella prophylaxis in exposed/ susceptible individual who will not consider a therapeutic abortion • Adult pregnant women: IM 0.55 mL/kg Immunoglobulin deficiency • Adult: IM 1.32 mL/kg, then 0.66 mL/ kg (≥100 mg/kg) q3-4wk Immune globulin IV (IVIG, IGIV) Primary immunodeficiency Gammagard S/D • Adult/adolescent/child: IV 300-600 mg/kg q3-4wk Polygam S/D • Adult/adolescent/child: IV 100 mg/kg/ mo; initially 200-400 mg/kg may be used Gammar-P IV • Adult: IV 200-400 mg/kg q3-4wk • Adolescent/child: IV 200 mg/kg q3-4wk Gamunex • Adult/adolescent/child: IV INFUSION 300-600 mg/kg (3-6 mL/kg) q3-4wk, initial infusion rate 1 mg/kg/min (max 8 mg/kg/min) Iveegam EN • Adult/adolescent/child: IV 200 mg/kg monthly, max 800 mg/kg/mo Carimune NF • Adult/adolescent/child: IV 200 mg/ kg/mo Gammagard Liquid/Flebogamma 5% • Adult/adolescent/child: IV 300-600 mg/kg q3-4wk Privigen • Adult/adolescent/child ≥3 yr: IV 200- 800 mg q3wk Idiopathic thrombocytopenic purpura (ITP) Carimune NF • Adult/child: IV 400 mg/kg daily × 2-5 days; with acute ITP of childhood, only 2 of 5 days are needed if initial platelets are 30,000-50,000 microliters after 2 doses Gammagard S/D/Polygam S/D • Adult/adolescent/child: IV 1000 mg/ kg as a single dose; may give on alternate days for up to 3 doses Gamunex • Adult/adolescent/child: IV INFUSION total dose of 2000 mg/kg on 2 consecu- tive days; initial rate is 1 mg/kg/min (max 8 mg/kg/min); if after 1st dose adequate platelets are observed after 24 hr, may withhold 2nd dose Privigen • Adult/adolescent ≥15 yr: IV 1 g/kg/ day × 2 days Kawasaki disease Iveegam EN • Child: IV 400 mg/kg daily × 4 consecu- tive days or a single dose of 2000 mg/kg over 10 hr, given with aspirin 100 mg/kg/ day through 14th day of illness, then 3-5 mg/kg each day thereafter for 5 wk Gammagard S/D/Polygam S/D • Infant/child: IV 1000 mg/kg as a single I dose or 400 mg/kg/day × 4 days beginning within 7 days of fever onset, with aspirin 80-100 mg/kg/day × 4 divided doses Immune globulin SC (SCIG/IGSC) • Adult/child >2 yr: SUBCUT INFUSION 100-200 mg/kg weekly, Vivaglobin brand of SCIG 160 mg IgG/mL, SUBCUT inj 15 mL/inj site, given at max of 20 mL/hr Hizentra • Adult/child: multiply the previous IVIG dose by 1.37, then divide into weekly dose based on previous week treatment
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• Adult/geriatric/adolescent/child/infant (unlabeled): IM 0.02 mL/kg for those who have not received hepatitis A vaccine and have been exposed during the prior 2 wk Measles prophylaxis (exposed during prior 6 days)
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• Child (unlabeled): IM 0.5 mL/kg as a single dose, max 15 mL (immunocom- promised) Varicella prophylaxis
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• Adult/adolescent/child: IV 300-600 mg/kg q3-4wk Polygam S/D
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• Adult/adolescent/child: IV 100 mg/kg/ mo; initially 200-400 mg/kg may be used Gammar-P IV
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• Adolescent/child: IV 200 mg/kg q3-4wk Gamunex
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• Adult/adolescent/child: IV INFUSION 300-600 mg/kg (3-6 mL/kg) q3-4wk, initial infusion rate 1 mg/kg/min (max 8 mg/kg/min) Iveegam EN
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• Adult/adolescent/child: IV 200 mg/kg monthly, max 800 mg/kg/mo Carimune NF
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• Adult/adolescent/child: IV 200 mg/ kg/mo Gammagard Liquid/Flebogamma 5%
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• Adult/adolescent/child: IV 300-600 mg/kg q3-4wk Privigen
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• Adult/adolescent/child ≥3 yr: IV 200- 800 mg q3wk Idiopathic thrombocytopenic purpura (ITP) Carimune NF
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• Adult/child: IV 400 mg/kg daily × 2-5 days; with acute ITP of childhood, only 2 of 5 days are needed if initial platelets are 30,000-50,000 microliters after 2 doses Gammagard S/D/Polygam S/D
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• Adult/adolescent/child: IV 1000 mg/ kg as a single dose; may give on alternate days for up to 3 doses Gamunex
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• Adult/adolescent/child: IV INFUSION total dose of 2000 mg/kg on 2 consecu- tive days; initial rate is 1 mg/kg/min (max 8 mg/kg/min); if after 1st dose adequate platelets are observed after 24 hr, may withhold 2nd dose Privigen
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• Child: IV 400 mg/kg daily × 4 consecu- tive days or a single dose of 2000 mg/kg over 10 hr, given with aspirin 100 mg/kg/ day through 14th day of illness, then 3-5 mg/kg each day thereafter for 5 wk Gammagard S/D/Polygam S/D
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• Infant/child: IV 1000 mg/kg as a single I dose or 400 mg/kg/day × 4 days beginning within 7 days of fever onset, with aspirin 80-100 mg/kg/day × 4 divided doses Immune globulin SC (SCIG/IGSC)
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• Adult/child >2 yr: SUBCUT INFUSION 100-200 mg/kg weekly, Vivaglobin brand of SCIG 160 mg IgG/mL, SUBCUT inj 15 mL/inj site, given at max of 20 mL/hr Hizentra
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• Adult/child: multiply the previous IVIG dose by 1.37, then divide into weekly dose based on previous week treatment
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