Drug reference
Hypertension ▶BY MOUTH ▶Adult: Initially 25 mg twice daily, increased in steps of 25–50 mg every 2 weeks, maximum daily dose should be given in divided doses; maximum 200 mg per day Benign prostatic hyperplasia ▶BY MOUTH ▶Adult: 20 mg twice daily, increased in steps of 20 mg every 2 weeks if required, increased if necessary up to 100 mg daily in divided doses ▶Elderly: 20 mg daily may be adequate, dose to be taken at night
PDF page 849
DUE TO INTERACTIONS ▶Caution with concomitant antihypertensives in benign prostatic hyperplasia—reduced dosage and specialist supervision may be required.
PDF page 849
Established heart failure. history micturition syncope (when used for benign prostatic hyperplasia). history of postural hypotension (when used for benign prostatic hyperplasia)
PDF page 849
Cataract surgery (risk of intra-operative floppy iris syndrome). control incipient heart failure before initiating indoramin. elderly. epilepsy (convulsions in animal studies). history of depression. Parkinson’s disease (extrapyramidal disorders reported) CAUTIONS, FURTHER INFORMATION ▶Elderly For alpha1-selective adrenoceptor blockers, Genito-urinary system prescription potentially inappropriate (STOPP criteria): . in those with symptomatic orthostatic hypotension or micturition syncope (risk of precipitating recurrent syncope) . in those with persistent postural hypotension i.e. recurrent drop in systolic blood pressure 20 mmHg (risk of syncope and falls). See also Prescribing in the elderly p. 33.
PDF page 849
→Appendix 1: alpha blockers
PDF page 849
▶Rare or very rare Parkinson’s disease exacerbated ▶Frequency not known Depression. dizziness. drowsiness. dry mouth. ejaculation failure. fatigue. headache. nasal congestion. weight increased
PDF page 849
No evidence of teratogenicity; manufacturers advise use only when potential benefit outweighs risk.
PDF page 849
No information available.
PDF page 849
Manufacturer advises caution.
PDF page 849
Manufacturer advises caution.
PDF page 849
There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Indoramin (Non-proprietary) Indoramin (as Indoramin hydrochloride) 20 mg Indoramin 20mg tablets | 60 tablet P £61.00 DT = £11.08 Indoramin (as Indoramin hydrochloride) 25 mg Indoramin 25mg tablets | 84 tablet P £60.26 DT = £60.26 ▶Doralese Tiltab (Chemidex Pharma Ltd) Indoramin (as Indoramin hydrochloride) 20 mg Doralese Tiltab 20mg tablets | 60 tablet P £11.44 DT = £11.08
PDF page 849
Driving and skilled tasks Drowsiness may affect performance of skilled tasks (e.g. driving); effects of alcohol may be enhanced.
PDF page 849
20 mg daily may be adequate, dose to be taken
First-line fragment. Read the complete Indications and Dose section above.
PDF page 849
