Drug Action
Influenza vaccines protect people at high risk from influenza and reduce transmission of infection; the nasal spray contains live attenuated strains, all other vaccines are inactivated.
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Drug reference
Influenza vaccines protect people at high risk from influenza and reduce transmission of infection; the nasal spray contains live attenuated strains, all other vaccines are inactivated.
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Annual immunisation against seasonal influenza ▶BY INTRAMUSCULAR INJECTION ▶Child 6 months–17 years: 0.5 mL for 1 dose ▶Adult: 0.5 mL for 1 dose ▶BY INTRADERMAL INJECTION ▶Adult 18–59 years: 9 micrograms for 1 dose, dose to be injected into deltoid region ▶Adult 60 years and over: 15 micrograms for 1 dose, dose to be injected into deltoid region ▶BY INTRANASAL ADMINISTRATION ▶Child 2–17 years: 0.1 mL for 1 dose, dose to be administered into each nostril Annual immunisation against seasonal influenza (for children in clinical risk groups who have not received seasonal influenza vaccine previously) ▶BY INTRAMUSCULAR INJECTION ▶Child 6 months–8 years: 0.5 mL for 1 dose, followed by 0.5 mL for 1 dose, after at least 4 weeks ▶BY INTRANASAL ADMINISTRATION ▶Child 2–8 years: 0.1 mL for 1 dose, followed by 0.1 mL for 1 dose, after at least 4 weeks. 0.1 mL dose to be administered to each nostril l UNLICENSED USE The Joint Committee on Vaccination and Immunisation advises offering a second dose of vaccine for annual immunisation against seasonal influenza to children in clinical risk groups only.
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Preparations marketed by Pfizer, or CSL Biotherapies in child under 5 years—increased risk of febrile convulsions FLUENZ TETRA ® Active wheezing. concomitant use with antiviral therapy for influenza. severe asthma CONTRA-INDICATIONS, FURTHER INFORMATION ▶Concomitant use with antiviral therapy for influenza Public Health England advises avoid immunisation for at least 48 hours after stopping the influenza antiviral agent. Administration of influenza antiviral agents within two weeks of Fluenz Tetra® administration may reduce the effectiveness of the vaccine.
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Increased risk of fever in child 5–9 years with preparations marketed by Pfizer or CSL Biotherapies—use alternative influenza vaccine if available
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Individuals with a history of egg allergy can be immunised with either an egg free influenza vaccine, if available, or an influenza vaccine with an ovalbumin content less than 120 nanograms/mL (facilities should be available to treat anaphylaxis). Vaccines with an ovalbumin content more than 120 nanograms/mL or where content is not stated should not be used in individuals with egg allergy. If an influenza vaccine containing ovalbumin is being considered in those with a history of anaphylaxis to egg or egg allergy with uncontrolled asthma, these individuals should be referred to a specialist in hospital.
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The available preparations are not licensed for use in all age- groups—further information can be found in the product literature for the individual vaccines. FLUARIX TETRA ® Ovalbumin content less than 100 nanograms/mL.
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→Appendix 1: live vaccines
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▶Common or very common ▶With intradermal use Chills. local reactions. pain ▶With intramuscular use Chills (uncommon in elderly). hyperhidrosis. induration. local reactions. pain (uncommon in elderly) ▶With intranasal use Nasal complaints ▶Uncommon ▶With intradermal use Hyperhidrosis ▶With intramuscular use Cough ▶With intranasal use Epistaxis. face oedema ▶Rare or very rare ▶With intradermal use Nerve disorders. paraesthesia ▶With intramuscular use Vasodilation ▶Frequency not known ▶With intradermal use Angioedema. encephalomyelitis. febrile seizure. nervous system disorder. shock. thrombocytopenia. vasculitis ▶With intramuscular use Angioedema. asthenia. chest pain. dyspnoea. extensive swelling of vaccinated limb. eye erythema. increased risk of infection. nerve disorders. nervous system disorders. paraesthesia. seizures. shock. syncope. throat tightness. thrombocytopenia. vasculitis. wheezing ▶With intranasal use Guillain-Barre syndrome
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Inactivated vaccines not known to be harmful. FLUENZ TETRA ® Avoid in pregnancy.
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Inactivated vaccines not known to be harmful. FLUENZ TETRA ® Avoid in breast-feeding.
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There can be variation in the licensing of different medicines containing the same drug. Spray EXCIPIENTS: May contain Gelatin, gentamicin ▶Fluenz Tetra (AstraZeneca UK Ltd) Fluenz Tetra vaccine nasal suspension 0.2ml unit dose | 10 unit dose P £180.00 Suspension for injection EXCIPIENTS: May contain Gentamicin, kanamycin, neomycin, polymyxin b A ▶Influenza vaccine (non-proprietary) Influenza vaccine (split virion, inactivated) suspension for injection 0.5ml pre-filled syringes | 10 pre-filled disposable injection P £65.90 Quadrivalent influenza vaccine (split virion, inactivated) suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £8.00 | 10 pre-filled disposable injection P £80.00 Influenza Tetra MYL vaccine suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £8.00 | 10 pre-filled disposable injection P £80.00 Adjuvanted trivalent influenza vaccine (surface antigen, inactivated) suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £9.79 | 10 pre-filled disposable injection P £97.90 ▶Fluad (Seqirus Vaccines Ltd) Fluad vaccine suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £9.79 | 10 pre-filled disposable injection P £97.90 ▶Fluarix Tetra (GlaxoSmithKline UK Ltd) Fluarix Tetra vaccine suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £9.94 | 10 pre-filled disposable injection P £99.40 ▶Flucelvax Tetra (Seqirus Vaccines Ltd) A Flucelvax Tetra vaccine suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £9.94 | 10 pre-filled disposable injection P £99.40 ▶Imuvac (Mylan) Imuvac vaccine suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £6.59 | 10 pre-filled disposable injection P £65.90 ▶Influvac Sub-unit (Mylan) A Influvac sub-unit Tetra vaccine suspension for injection 0.5ml pre-filled syringes | 1 pre-filled disposable injection P £9.94 | 10 pre-filled disposable injection P £99.40 eiiii F 1379
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FLUENZ TETRA ® Avoid close contact with severely immunocompromised patients for 1–2 weeks after vaccination.
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0.5 mL for 1 dose
First-line fragment. Read the complete Indications and Dose section above.
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9 micrograms for 1 dose, dose to be
First-line fragment. Read the complete Indications and Dose section above.
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15 micrograms for 1 dose, dose
First-line fragment. Read the complete Indications and Dose section above.
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